Advanced Chemical Biology

Advanced Chemical Biology is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections.

Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course.

Written by authors and editors coming from the leading scientific institutions that have developed the concepts and technologies for this discipline, Advanced Chemical Biology includes specific information on topics like:

• DNA function, synthesis and engineering, chemical approaches to genome integrity, and RNA function, synthesis, and probing
• Chemical approaches to transcription and RNA regulation in vivo, chemical biology of genome engineering, and peptide/protein synthesis and engineering
• Directed evolution for chemical biology, chemical biology of cellular metabolism, chemical biology of lipids, and protein post-translational modifications

• Chemical glycobiology, chemical and enzymatic modification of proteins, genetic code expansion, bio-orthogonal chemistry, and cellular imaging

  With its broad scope and focus on turning concepts into applications, Advanced Chemical Biology is an excellent starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer.

  With a Foreword by Nobel Laureate Carolyn Bertozzi.

  Interessante Richtung des Lehrbuches, stärker aus chemischer Perspektive betrachtet. Erweitert dadurch den Blickwinkel aufs Fach gerade für Wissenschaftler die stärker aus der biologischen Richtung kommen.
  Prof. Dr. David Kostner, Hochschule München, Biotechnologie (11/2023)

  Autorentext
  Howard C. Hang, Ph.D.
  B.Sc. in Chemistry 1998, University of California, Santa Cruz (Joseph Konopelski)
  Ph.D. in Chemistry 2003, University of California, Berkeley (Carolyn Bertozzi)
  Damon Runyon Postdoctoral Fellow 2004 - 2006, Whitehead Institute (Hidde Ploegh)
  Assistant Professor and Head of Lab, 2007 - 2012, The Rockefeller University
  Associate Professor and Head of Lab, 2013 - present, The Rockefeller University
  Awards: Irma T. Hirschl/Monique Weill-Caulier Trust Research Award, 2007; Ellison Medical Foundation New Scholar Award, 2008; The Rockefeller University Distinguished Teaching Award, 2011; Eli Lilly Award in Biological Chemistry, 2017

  Matthew R. Pratt, Ph.D.
  B.S. in Biochemistry and Math 1999, University of Arizona, Tucson (Robin Polt)
  Ph.D. in Chemistry 2004, University of California, Berkeley (Carolyn Bertozzi)
  American Cancer Society Fellow 2005-2009, Rockefeller University (Tom Muir)
  Associate Professor, University of Southern California, Los Angeles
  Awards: Damon Runyon Rachleff-Innovator (2011), USC General Education Teaching Award (2013), Susan G. Komen Career Catalyst Award (2014), American Cancer Society Research Scholar (2015), American Chemical Society - David Y. Gin Young Investigator Award (2015), American Cancer Society Hope Award (2016).

  Jennifer A. Prescher, Ph.D.
  B.S. in Chemistry and Mathematics 2001, University of Wisconsin-La Crosse (Aaron Monte)
  Ph.D. in Chemistry 2006, University of California, Berkeley (Carolyn Bertozzi)
  Susan G. Komen and Molecular Imaging Fellow, Stanford University, 2007 - 2010 (Chris Contag)
  Assistant Professor, 2010 - 2016, University of California, Irvine
  Associate Professor, 2016 - 2018, University of California, Irvine
  Full Professor, 2018 - Present, University of California, Irvine
  Awards: Scialog Fellow (2018), UCI Distinguished Assistant Professor Award for Research (2016), ACS Women in Chemistry Rising Star (2016), Thieme Chemistry Journal Award (2016), Novartis Early Career Award in Organic Chemistry (2015), Camille and Henry Dreyfus Teacher-Scholar (2015), Alfred P. Sloan Research Fellowship (2015), NSF CAREER Award (2014), Cottrell Scholar (2014), Kavli Fellow (2014), UCI Outstanding Contributions to Undergraduate Education Award (2013)

  Klappentext

  The modern approach to teaching chemical biology Advanced Chemical Biology is organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections. Every chapter is homogeneous in style and layout, consisting of a short historical introduction followed by a description of the underlying concepts and a selection of recent examples of how the concept has been turned into practice. The subdivision of the contents into core and supplemental chapters enables a flexible use in teaching, both for a one-semester and a two-semester course. Written by authors and editors coming from the leading scientific institutions that have developed the concepts and technologies for this discipline, Advanced Chemical Biology includes specific information on topics like:

• DNA function, synthesis and engineering, chemical approaches to genome integrity, and RNA function, synthesis, and probing
• Chemical approaches to transcription and RNA regulation in vivo, chemical biology of genome engineering, and peptide/protein synthesis and engineering
• Directed evolution for chemical biology, chemical biology of cellular metabolism, chemical biology of lipids, and protein post-translational modifications

• Chemical glycobiology, chemical and enzymatic modification of proteins, genetic code expansion, bio-orthogonal chemistry, and cellular imaging With its broad scope and focus on turning concepts into applications, Advanced Chemical Biology is an excellent starting point for anyone entering the field and looking for a guide to the wide range of available methods and strategies that chemical biology has to offer. With a Foreword by Nobel Laureate Carolyn Bertozzi.

  Inhalt
  Introduction to Advanced Chemical Biology
  DNA Function, Synthesis and Engineering
  Chemical Approaches to Genome Integrity
  RNA function, synthesis, and probing
  Chemical Approaches to Transcription and RNA Regulation In Vivo
  Chemical Biology of Genome Engineering
  Peptide Synthesis and Engineering
  Protein Synthesis and Engineering
  Directed Evolution for Chemical Biology
  Chemical Biology of Cellular Metabolism
  Chemical Biology of Lipids
  Protein Post-Translational Modifications
  Chemical Glycobiology
  The Chemical and Enzymatic Modification of Proteins
  Genetic Code Expansion
  Bioorthogonal Chemistry
  Cellular Imaging
  In Vivo Imaging
  Chemical Biology of Metals
  Chemical Approaches Towards Redox Biology
  Activity-Based Protein Profiling
  Chemical Genetics
  Natural Product Discovery
  Natural Product Biosynthesis
  Chemical Microbiology
  Chemical Approaches to Analyze Biological Mechanisms and Overcome Resistance to Therapeutics
  Chemical Developmental Biology
  Chemical Immunology
  Chemical Neurobiology
  Small Molecule Drug Discovery