Effects of Punica granatum and/ or Sitagliptin on diabetic nephropathy in male rats

Type 2 diabetes mellitus (T2DM) represents about 90% of diabetic cases. Diabetic nephropathy is one of the most serious complications of diabetes. Sitagliptin has an important role in enhancement of the Glucagon-like peptide receptor (GLP-1R) which present in the kidneys, so it may have a role in enhancement of the kidney function in T2DM. Also, Punica granatum peels extract (PGPE) is a herb which has an anti-hyperglycemic and antioxidant activities. This study was designed to investigate the role of PGPE and/or sitagliptin on renal functions in induced diabetes. Results of the present work showed that administration of streptozotocin-nicotinamide induced oxidative stress, inflammation and hyperglycemia which play a significant role in diabetes and its complications. The improvement is due to the antidiabetic, anti-inflammatory, and antioxidative actions of sitagliptin and Punica granatum peels. The combination of Punica granatum and sitagliptin compared to monotherapy have better renoprotective effects in diabetic rats.

Autorentext

Hanan Essam MohamedBachelorder Medizin, Bachelor der Chirurgie, Universität Mansoura(2014).Masterstudentin in Physiologie an der Al-Azhar-Universität für MädchenAktuelleStelle: Demonstratorin in der Abteilung Physiologie, Medizinische Fakultät, Helwan-Universität.