Factor VIII
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Details
Factor VIII (FVIII) is an essential blood clotting factor also known as anti-hemophilic factor (AHF). In humans, Factor VIII is encoded by the F8 gene.Defects in this gene results in hemophilia A, a well known recessive X-linked coagulation disorder.Factor VIII participates in blood coagulation; it is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids forms a complex that converts factor X to the activated form Xa. The Factor VIII gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity.
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GarantieWeitere Informationen
- Allgemeine Informationen
- GTIN 09786130756499
- Editor Frederic P. Miller, Agnes F. Vandome, John McBrewster
- Größe H220mm x B6mm x T150mm
- EAN 9786130756499
- Format Fachbuch
- Titel Factor VIII
- Gewicht 156g
- Herausgeber Alphascript Publishing
- Anzahl Seiten 104
- Genre Biologie
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