Inflammasome Signaling and Bacterial Infections

This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic.

Presents a comprehensive collection of reviews on the multiple facets of inflammasome signal transduction Discusses the latest insights into the major components of known canonical and non-canonical inflammasome complexes Offers a valuable resource both for readers new to the field and for professionals already working in the area of inflammasomes Includes supplementary material: sn.pub/extras

Autorentext
Steffen Backert is a professor at Erlangen/Nuremberg University (Germany), Chair of Microbiology.

Inhalt
General strategies in inflammasome biology (overview).- Structural mechanisms in inflammasome assembly and signaling.- Salmonella enterica inflammasome.- Yersinia pestis inflammasome.- Shigella flexneri inflammasome.- Helicobacter pylori inflammasome.- Listeria monocytogenes inflammasome.- Legionella pneumophila inflammasome.- Mycobacterium inflammasome.- Burkholderia pseudomallei inflammasome.- Streptococcus pneumoniae inflammasome.- Franciscella tularensis inflammasome.- Staphylococcus aureus inflammasome.