Molecular Farming of Plants and Animals for Human and Veterinary Medicine

Molecular farming has been hailed as the "third wave" of genetically-modified organisms produced through biotechnology for the bio-based economy of the future. Unlike products of the first wave, such as herbicide resistant crop plants, which were perceived to benefit only the farmers who used them and the agrochemical companies who developed them, products of molecular farming are designed specifically for the benefit of the consumer. Such products could be purified from food or non-food organisms for a range of applications in industry, as well as animal and human health. Alternatively, the products of this technology could be consumed more directly in some edible format, such as milk, eggs, fruits or vegetables. There is a rapidly-growing interest Qn the part of the public as well as in the medical community in the role food plays in health, especially in the immunophysiological impact of food over and above the role of basic nutrition.

Inhalt

1. Tobacco, a Platform for the Production of Recombinant Proteins.- 2. Alfalfa: An Efficient Bioreactor for Continuous Recombinant Protein Production.- 3. The Use of Viral Vectors for the Production of Recombinant Proteins in Plants.- 4. Control of the N-Glycosylation of Therapeutic Glycoproteins Produced in Transgenic Plants: A New Challenge for Glycobiologists.- 5. Production and Commercialization of Biopharmaceuticals from Milk.- 6. A Seed-Derived Oral Subunit Vaccine for Human Cytomegalovirus.- 7. Use of Plant Virus-Based Expression Systems for the Production of HIV Vaccines.- 8. Suppression of Autoimmune Diabetes by the Use of Transgenic Plants Expressing Autoantigens to Induce Oral Tolerance.- 9. The Production and Delivery of Therapeutic Peptides in Plants.- 10. An Oral Vaccine in Maize Protects against Transmissible Gastroenteritis Virus in Swine.- 11. Production of Antibodies in Alfalfa (Medicago Sativa).- 12. The Production of Recombinant Antibodies in Plants and Plant Cells.- 13. Immunotherapeutic Potential of Antibodies Produced in Chicken Eggs.- 14. The Production of Recombinant Cytokines in Plants.- 15. Edible Vaccines in Plants for Livestock Pathogens.