Molecular properties prediction and synthesis of oxadiazole analogues

A series of 11 oxadiazole analogues were subjected to molecular properties prediction and drug likeness by Molinspiration and MolSoft software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski "Rule of five" were synthesized for antimicrobial screening as oral bioavailable drugs/leads. Further the structure of the synthesized compounds was confirmed by spectral analyses (IR, NMR and mass) and the compounds (4a-k) were evaluated for antibacterial and antifungal activities as per the standard protocol. N-(2-Methylphenyl)-5-(4-chlorophenyl)-1,3,4-oxadiazol-2-amine, 4c was found to have maximum antibacterial activity while N-(2-methylphenyl)-5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-amine, 4d showed maximum antifungal activity.

Autorentext

Dr. Rakesh Sharma (UGC NET-JRF & JKSET) erwarb seinen Doktortitel an der Panjab University, Chandigarh. Er hat auch mehrere Forschungsarbeiten im Bereich der Humangeographie veröffentlicht. Außerdem hat er auf verschiedenen internationalen und nationalen Konferenzen, die von verschiedenen Organisationen wie DGSI, IGU, Panjab Geographer, NAGI, APGI usw. organisiert wurden, Vorträge gehalten.