Mouse Myosin XVa

Myosins comprise a class of molecular motors that
move along actin filaments and deliver cargo to
specific cellular compartments. This book provides a
detailed examination of the mouse myosin XVa
biological function, characterization of full-length
mouse inner ear myosins VIIa, VIIb, X and XVa cDNA
transcripts and the cellular targeting of myosins
VIIa, VIIb, X and XVa in mouse inner ear hair cells.
Stereocilia are actin-filled projections on the
apical surface of inner ear hair cells that detect
mechanical stimuli of sound and head movement. The
precise arrangement of stereocilia rows in a
staircase-like pattern required for normal function
is disrupted by the failure of myosin XVa to deliver
whirlin to stereocilia tips resulting in deafness and
vestibular defects. In transfected mouse hair cells
deficient for myosin XVa function, the domains of
myosin XVa required for stereocilia tip targeting
were different than those required in the
re-initiation of stereocilia elongation and staircase
formation. The information in this book should be
especially useful to investigators in the fields of
neuroscience, biophysics, genetics and cell biology.

Autorentext

Erich T.A. Boger, Ph.D. Biology. Research Scientist at NationalInstitute on Deafness and Other Communication Disorders, NationalInstitutes of Health. Bethesda, Maryland.

Klappentext

Myosins comprise a class of molecular motors thatmove along actin filaments and deliver cargo tospecific cellular compartments. This book provides adetailed examination of the mouse myosin XVabiological function, characterization of full-lengthmouse inner ear myosins VIIa, VIIb, X and XVa cDNAtranscripts and the cellular targeting of myosinsVIIa, VIIb, X and XVa in mouse inner ear hair cells.Stereocilia are actin-filled projections on theapical surface of inner ear hair cells that detectmechanical stimuli of sound and head movement. Theprecise arrangement of stereocilia rows in astaircase-like pattern required for normal functionis disrupted by the failure of myosin XVa to deliverwhirlin to stereocilia tips resulting in deafness andvestibular defects. In transfected mouse hair cellsdeficient for myosin XVa function, the domains ofmyosin XVa required for stereocilia tip targetingwere different than those required in there-initiation of stereocilia elongation and staircaseformation. The information in this book should beespecially useful to investigators in the fields ofneuroscience, biophysics, genetics and cell biology.