Nanotechnology and Neuroscience: Nano-electronic, Photonic and Mechanical Neuronal Interfacing

This book examines modern micro- and nanofabrication technologies to develop improved tools for stimulating and recording electrical activity in neuronal networks. It discusses the compatibility of fabrication techniques optimized for different devices.

This book describes the use of modern micro- and nanofabrication technologies to develop improved tools for stimulating and recording electrical activity in neuronal networks. It provides an overview of the different ways in which the nano-world can be beneficial for neuroscientists, including improvement of mechanical adhesion of cells on electrodes, tight-sealed extracellular recordings or intracellular approaches with strongly reduced invasiveness and tools for localized electrical or optical stimulation in optogenetics experiments. Specific discussion of fabrication strategies is included, to provide a comprehensive guide to develop micro and nanostructured tools for biological applications. A perspective on integrating these devices with state-of-the-art technologies for large-scale in vitro and in vivo experiments completes the picture of neuronal interfacing with micro- and nanostructures.

Provides readers with state-of-the-art information about developing advanced nanotechnology tools for communicating with the brain Includes discussion of the compatibility of fabrication techniques optimized for different target devices, such as electric sensors/transducers based on metallic or semiconductor interfaces and optical probes to guide light into the brain Offers a single-source reference to the mechanical, electrical and optical effects of nanostructures on neurons Includes supplementary material: sn.pub/extras

Klappentext

This book provides an overview of the different ways in which the nano-world can be beneficial for neuroscientists. The volume encompasses the latest developments in the field of micro- and nanotechnology applied to neuroscience, discussing technological approaches applied to both in-vitro and in-vivo experiments. A variety of different nanotechnologies are presented that include nanostructured electrodes and their electrical, mechanical and biochemical properties, active and passive 2D and 3D multi-electrode arrays (MEAs), nanoscale transistors for sub-cellular re-cordings and an overview on methods, tools and applications in optoge-netics.

The book focuses specifically on fabrication strategies, to offer a compre-hensive guide for developing and applying micro- and nanostructured tools for neuroscientific applications. It is intended as a reference both for neuroscientists and nanotechnologists on the latest developments in neu-rotechnological tools.

• Provides readers with state-of-the-art information about developing advanced nanotechnology tools for communicating with the brain;
• Includes discussion of the compatibility of fabrication techniques optimized for different target devices, such as electric sensors/transducers based on metallic or semiconductor interfaces and optical probes to guide light into the brain;
• Offers a single-source reference to the mechanical, electrical and optical effects of nanostructures on neurons.

Inhalt
Nanotechnology and Neuroscience: nano-electronic, photonic and mechanical neuronal interfacing.- Carbon nanotubes for neuron-electrode interface with improved mechanical performance.- Nanoscale field-effect transistors for minimally invasive, high spatial resolution and three-dimensional action potential recording.- In-cell recording and stimulation by engulfment mechanisms.-Micromachining Techniques for Realization of Three-Dimensional Microelectrode Arrays.- Focused ion beam technology as a fabrication and inspection tool in neuron interfacing.- Active Pixel Sensor Multi Electrode Array for high spatio-temporal resolution.- Multi electrode and multi transistor arrays for in vivo recording.- Optogenetics.