Radiosensitivity
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Radiosensitivity is the relative susceptibility of cells, tissues, organs or organisms to the harmful effect of ionizing radiation. Cells are least sensitive when in the S phase, then the G1 phase, then G2 phase and the most sensitive in the M phase of the cell cycle. This is described by the law of Bergonie and Tribondeau, formulated in 1906: "X-rays are more effective on cells which have a greater reproductive activity." From their observation, they concluded that quickly dividing tumor cells are generally more sensitive than the majority of body cells. This is not always true. Tumor cells can be hypoxic and therefore less sensitive to X-rays that mediate most of their effects through free radicals produced by ionizing oxygen. Later it has been shown that the most sensitive cells are those that are undifferentiated, well nourished, divide quickly and are highly metabolically active. Amongst the body cells, the most sensitive are spermatogonia and erythroblasts, epidermal stem cells, gastrointestinal stem cells. The least sensitive are nerve cells and muscle fibers.
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GarantieWeitere Informationen
- Allgemeine Informationen
- GTIN 09786131365010
- Editor Lambert M. Surhone, Mariam T. Tennoe, Susan F. Henssonow
- Größe H220mm x B220mm
- EAN 9786131365010
- Titel Radiosensitivity
- Herausgeber Betascript Publishing
- Anzahl Seiten 328
- Genre Biologie
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