Synthetic Organic Sonochemistry

TEAN-LOUIS LUCHE A French poet of this eentury, Pierre Mae Orlan, wrote "Adventure does not exist, it is only in the mind of he who is pursuing it, and, as soon as it is at one's finger tips, it vanishes to come back to life, far away, in a different shape, at the frontiers of imagination". This sentence could be used to define the adventure that many sonochemists experienced. Most of them did not even suspect that the "laboratory trick" they were using was the first contact with a considerable amount of science. If a personal note is allowed here, it ean be interesting to mention the part played by chance in my involvement in sonochemistry. Almost 20 years ago, we had to perform an apparently simple Grignard reaetion with n-butylmagnesium bromide and geranial, but the results were repeatedly unsatisfactory. The one-pot Barbier technique was attempted, also without success. From my studies at the University, I imagined that the failure of the latter reaction could be caused by a common phenomenon known by solid state chemists as passivation, which in some cases can be overcome by ultrasonication. By chance, an ultrasonie bath was sitting on the next beneh, borrowed to clean some equipment. We clamped our reluctant reaction mixture into the bath, the reaction proceeded vigorously, and ... the adventure started. Without knowing anything about cavitation, high energies, ete., we had an illustration of Goethe's word "Am Anfang war die Tat" (at the Beginning was the Act).

Klappentext

The use of ultrasound in chemistry - sonochemistry - has grown spectacularly in recent years, resulting in a significant body of empirical research. This timely volume brings together the work and perspectives of theoreticians and acousticians, whose interest is centered on physical aspects, and of synthetic chemists, who need guidelines to successfully apply fundamental principles. br/ The text begins with a theoretical introduction hat summarizes the key physical principles of sonochemistry, keeping mathematics to a minimum. Seubseuqnet chapters describe the major characteristics of sonochemistry for solutions and for biphasic, catalytic, and electyrochemical syst6ems with the aim of elucidating the state of the art and of identifying major points for future study. br/ Highlights of emSynthetic Organic Sonochemistry/em include: /li li A selection of experimental procedures that illustrate important facets of ultrasound-mediated organic synthesis /li li A description of the relevant laboratory equipment with helpful suggestions on proper use, and /li li A valuable concluding section that delineates the successes of sonochemistry, less developed areas requiring further research, and possible links with other `new chemistries'.£/LIST£ br/ What this text does significantly better than any other competing text is to render sonochemistry as a technically simple, easily performed method that greatly enhances organic synthesis, even in industrial applications. For this reason, the book will be a welcome addition to the reference shelves of academic and industrial researachers and advanced-level students in organic and physcial chemistry, synthesis and mechanistic studies, acoustics, and high-energy processes.

Inhalt
1 - Theoretical Bases.- 2 - Sonochemistry of Solutions.- 3 - Cycloadditions.- 4 - Sonochemistry in Biphasic Systems.- 5 - Organometallic Sonochemistry.- 6 - Catalytic Reactions.- 7 - Organic Sonoelectrochemistry.- 8 - Practical Considerations for Process Optimization.- 9 - Selected Experiments.- Conclusions Sonochemistry: Quo Vadis?.- Author Index.