The ADAM Family of Proteases

The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer's amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.

The ADAM Family of Proteases will be a timely and useful source of information both for those immersed in the field and those just entering this exciting and rapidly expanding field of research. The individual chapters have been written by pioneers and experts in this area Provides an up-to-date presentation of the role of ADAM and ADAMTS proteases in biological processes Highlights the critical role played by these metalloproteases in various diseases Provides background information on the genetics, structure and function of each ADAM and ADAMTS protease Includes supplementary material: sn.pub/extras

Inhalt

Contributing Authors.- Preface.- Introduction to the ADAM Family, Judith White, Lance Bridges, Douglas DeSimone, Monika Tomczuk and Tyra Wolfsberg.- Studies from ADAM Knockout Mice, Keisuke Hoiruchi and Carl P. Blobel.- ADAM8/MS2/CD156a, Jörg W. Bartsch, Silvia Naus, Andrea Rittger, Uwe Schlomann, Dirk Wildeboer.- ADAM9, Shoichi Ishiura.- ADAM10, Paul Saftig and Dieter Hartmann.- ADAM12, Ulla M. Wewer, Reidar Albrechtsen and Eva Engvall.- Adam13 function in development, Dominique Alfandari, ADAM 17, Joaquín Arribas and Soraya Ruiz-Paz.- ADAM19, Tiebang Kang, Robert G. Newcomer, Yun-Ge Zhao and Qing-Xiang Amy Sang.- ADAM28, Anne M. Fourie.- Mammalian ADAMS with Testis-Specific Or -Predominant Expression, Chunghee Cho.- Overview OF ADAMTS Proteinases and ADAMTS-2, Daniel S. Greenspan and Wei-Man Wang.- ADAMTS-3 AND ADAMTS-14, Carine Le Goff and Suneel S. Apte.- ADAMTS-4 and ADAMTS-5, Anne-Marie Malfait, Micky Tortorella and Elizabeth Arner.- ADAMTS-13, Han-Mou Tsai.- Index.