Adrenergic System and Ventricular Arrhythmias in Myocardial Infarction

This book attempts to present new aspects on electrophysiologi cal mechanisms and catecholaminergic contributions in the set ting of acute and chronic myocardial ischemia. Special emphasis is placed on the full scope from basic molecular and cellular mechanisms to experimental models of close clinical proximity. A number of internationally distinguished scientists present their latest findings in this significant research area within the peri meter of cardiovascular disease which continues to lead mortality statistics in most industrialized countries. Contents of this book cover in addition to other subjects re lease and uptake of catecholamines in ischemia, regulation of re ceptors, adrenergic contribution to ventricular arrhythmias and mechanisms of ischemic malignant arrhythmias as well as un derlying changes in membrane currents and the electrophysiolog ical response to beta-adrenergic blocking drugs. In addition to original contributions, a number of editorial chapters are in cluded for conclusions and future development in these areas. The main purpose of this book is to provide further inside in two traditionally separated research topics that are gravitating to more collaborative work and inspire more joint research ventures in the future. It provides a comprehensive view on clinically sig nificant problems where basic research may stimulate further studies in man. Therefore this book may prove to be valuable to both cardiologists and interested clinicians as well as basic scien tists.

Klappentext

This book presents new aspects on electrophysiological mechanisms and catecholaminergic contributions in the setting of acute and chronic myocardial ischemia. Special emphasis is placed on the full scope from basic molecular and cellular mechanisms to experimental models of close clinical proximity. A number of internationally distinguished scientists present their latest findings in this significant research area within the perimeter of cardiovascular disease which continues to lead mortality statistics in most industrialized countries. Contents of this book cover, in addition to other subjects, release and uptake of catecholamines in ischemia, regulation of receptors, adrenergic contribution to ventricular arrhythmias and mechanisms of ischemic malignant arrhythmias as well as underlying changes in membrane currents and the electrophysiological response to beta-adrenergic blocking drugs. In addition to original contributions, a number of editorial chapters are included for conclusions and future development in these areas.

Inhalt
I Release of Catecholamines in Myocardial Ischemia.- Intracellular Requirements for Exocytotic Noradrenaline Release.- Neuropeptide Y and Sympathetic Transmission.- Influence of Myocardial Ischemia on Exocytotic Noradrenaline Release.- On the Mechanism of Nonexocytotic Release of Noradrenaline from Noradrenergic Neurons.- The Dynamics of Adrenergic Nerve Endings.- Increase of Cardiac and Systemic Catecholamines in Myocardial Ischemia.- II Adrenergic Receptors in Myocardial Ischemia.- Alpha1- and Beta-Adrenergic Receptors in Myocardial Ischemia and Injury.- Uncoupling of the ?-Adrenergic Receptor by Myocardial Ischemia.- Sensitization of the Adrenergic System in Early Myocardial Ischemia: Independent Regulation of ?-Adrenergic Receptors and Adenylate Cyclase.- Mechanisms of Altered Adrenergic Responsiveness Contributing to Arrhythmogenesis during Myocardial Ischemia.- Reflections of the Role of Adrenergic Mechanisms in Ventricular Arrhythmias.- III Ionic Mechanisms in Myocardial Ischemia.- Ionic Imbalance in Acute Myocardial Ischemia.- State-Dependent Block of Cardiac Na Currents by Ca Channel Antagonists.- Calcium Channels in the Heart.- The Cardiac K Current System.- Intracellular pH of Cardiac Cells: Hormonal Regulation and Role in Ischemia.- The Sympathetic Nervous System, Catecholamines and Ischemia-Induced Arrhythmias: Dependence upon Serum Potassium Concentration.- Towards a New Dimension of Cardiac Cellular Electrophysiology General Aspects.- IV Mechanisms of Arrhythmias.- Electrophysiologic Mechanisms for the Generation of Arrhythmias with Adrenergic Stimulation.- Catecholamine-Dependent Cardiac Arrhythmias: Mechanisms and Implications.- Mechanisms of Reentrant Arrhythmias.- Reentrant Ventricular Rhythms in the Canine Postinfarction Heart.- The Time Courseof Occurrence of Ventricular Arrhythmias after Experimental Myocardial Ischemia.- V Relation of Catecholamines and Ventricular Arrhythmias in Myocardial Ischemia.- Experimental Simulation of Sudden Cardiac Death in Humans: Electrophysiological Mechanisms and Role of Adrenergic Influences.- Ischaemia-Induced Noradrenaline Release Mediates Ventricular Arrhythmias.- Autonomic Innervation and Arrhythmias in Canine Myocardial Infarction.- Sympathetic Denervation, Supersensitivity, and Arrhythmogenesis after Myocardial Infarction.- Adrenergic System and Ventricular Arrhythmias in Acute Myocardial Ischemia: Multiple Feedback Mechanisms.- Why is Increased Adrenergic Activity Arrhythmogenic?.