Asymmetric Cell Division in Drosophila melanogaster Neuroblasts

Asymmetric cell divisions generate cell diversity. Drosophila neuroblasts divide in an asymmetric manner to generate another neuroblast and a differentiating ganglion mother cell. The adaptor protein Miranda plays a crucial role in creating intrinsic differences in the two daughter cells by asymmetrically localizing key differentiation factors. This thesis describes the identification of potential new components of Miranda complexes. The performed experiments provide a starting point for further investigations on the role of the versatile and multifunctional Miranda protein in Drosophila melanogaster development.

Autorentext

Diana Alia Laura Langer, Dr. rer. nat. : Diploma in Biology at the University of Munich. PhD thesis on Asymmetric Cell Division in Drosophila melanogaster Neuroblasts at the Gene Center in Munich. Postdoctoral studies on the role of noncoding RNAs in Dosage Compensation in Drosophila melanogaster at the Adolf-Butenandt-Institute in Munich.