Computational Study of Fluid Particles

A computational study of drops, capsules, cells andtheir emulsions is presented here motivated by theirdiverse applications in industries and biologicalscience. Particle deformation is the focus of thisstudy. Front-tracking method is developed toinvestigate deformation and interactions.Inertia-induced drop behavior gives rise to unusualrheological responses such as shear thickening and asign change of normal stresses in shear, and anegative elastic modulus in an oscillatingextensional flow.Simulation is also applied to explore the mechanicsof capsules and biological cells with constitutivemodels for membrane elasticity and molecular adhesionincorporated into the numerical framework. Celldeformation induces a hydrodynamic lift affectingcell adhesion to a substrate. Deformable cells detachfrom the substrate at the same bond parameters whererigid ones do not, indicating importance ofdeformation on the leukocyte adhesion cascade.

Autorentext

Dr. Xiaoyi Li obtained his PhD in Mechanical Engineering from University of Delaware with Allan P. Colburn Best Dissertation Award in May 2007. He is a Research Associate at Idaho National Lab. Dr. Kausik sarkar is an Associate Professor of Mechanical Engineering in University of Delaware. His research is in Fluid Mechanics and Biomechanics.

Klappentext
A computational study of drops, capsules, cells and their emulsions is presented here motivated by their diverse applications in industries and biological science. Particle deformation is the focus of this study. Front-tracking method is developed to investigate deformation and interactions. Inertia-induced drop behavior gives rise to unusual rheological responses such as shear thickening and a sign change of normal stresses in shear, and a negative elastic modulus in an oscillating extensional flow. Simulation is also applied to explore the mechanics of capsules and biological cells with constitutive models for membrane elasticity and molecular adhesion incorporated into the numerical framework. Cell deformation induces a hydrodynamic lift affecting cell adhesion to a substrate. Deformable cells detach from the substrate at the same bond parameters where rigid ones do not, indicating importance of deformation on the leukocyte adhesion cascade.