Mouse Models of Human Blood Cancers

Dr. Li and his Jackson Laboratory team emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The Jackson Laboratory is the world's largest mouse genetics institution.

In this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try to cover as much as they can the cancer types and point out that many blood cancers need to be studied in mouse disease models although they are still not available at present. A major focus in the book will be to show what we can or cannot learn from mouse disease models and to also show the critical contributions of mouse models in therapeutic drug development.

Most importantly, this book will be very highly respected because it is coming out of The Jackson Laboratory, which is the largest and most famous mouse genetics institution in the world The editor has invited several experts at The Jackson Laboratory and they've agreed to author chapters Includes supplementary material: sn.pub/extras

Klappentext

Although it remains an open question among some people whether mice and humans are similar in disease development, the laboratory mouse has emerged as the preeminent animal model for human diseases. This is underscored by the recently completed mouse and human genome projects, which have revealed that mice and humans share the vast majority of their genes, and thus get many of the same diseases, and for the same reasons. Emphasizing why mouse models are valuable in vivo systems for understanding disease mechanisms and developing therapeutic strategies for human blood cancers, "Mouse Models of Human Blood Cancers: Basic Research and Pre-clinical Applications," edited by Shaoguang Li, aims on presenting thorough analyses of the pathological features and the molecular bases of several major types of blood cancer and to describe translational research using mouse cancer models.

Inhalt
Mouse Models of Myeloproliferative Disease Associated with Mutant JAK2 Tyrosine Kinase: Insights into Pathophysiology and Therapy.- Genetic Modeling of Human Blood Cancers in Mice.- Murine Models of Hematopoietic Disease: Pathologic Analysis and Characterization.- Mechanisms of DNA Double-Strand Break Repair in Hematopoietic Homeostasis and Oncogenesis.- Modeling Human Leukemia Using Immune-Compromised Mice.- Dietary Restriction: A Model System Probing the Cell Fate Decision Between Cancer and Senescence.- Modeling Human Philadelphia Chromosome-Positive Leukemia in Mice.- Mouse Models of Human Mature B-Cell and Plasma Cell Neoplasms.- Genetic and Virological Predisposition to Pre-B Lymphomagenesis in SL/Kh.- Animal Cancer Models in Anticancer Drug Discovery and Development.- DGL Global Strategies in DNA Microarray Gene Expression Analysis and Data Mining for Human Blood Cancers.