Stem Cells and Human Diseases

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

Mechanisms by which stem cell regulate regulate cellular function and normal organ development Mechanisms by which cancer stem cells regulate cancer initiation and progression Role of cancer stem cells in drug resistance Signaling pathways regulating self-renewal capacity of normal stem cells and cancer stem cells Development of novel drugs to target cancer stem cells Role of microRNA and genes in stem cells and cancer stem cells Genetic and proteomic profiling in stem cells

Klappentext

There have been major advances in understanding the behavior of stem cells and their roles in tissue regeneration, homeostasis and therapy. Cancer stem cell hypothesis opened a new opportunity for treating and preventing cancers by targeting cancer stem cells or cancer initiating cells. An increased understanding of stem cell behavior and biology along with rapid advancement of high throughput screening has led to the discovery and development of novel drugs that control stem cell self-renewal and differentiation. In near future, these molecules will be very useful for treating and preventing several human diseases.

While progress on the clinical front has been slower than desired, the use of stem cells for tissue regeneration and disease management has great potential in human health.

The first decade of the 21st century has brought with it significant progress in our understanding of stem cell or progenitor cells and their role in tissue regenerationand management of human diseases including cancer, neurodegenerative disorders, and heart diseases. This book covers the current state-of-the-art knowledge on the role of stem cells in tissue regeneration, homeostasis and disease management.

Features:

• Coverage of the biology of stem cell and their role in tissue regeneration and organogenesis.
• Mechanism-based strategies for stem cell self-renewal and differentiation.
• Role of cancer stem cells or tumor initiating cells in cancer initiation, progression, relapse and drug resistance.

• Use of stem cells in treating several human diseases, such as Alzheimer's disease, Parkinson's disease, cancer and diabetes.

  Inhalt

  1. Cancer Stem Cells: Biology, Perspectives and Therapeutic Implications.- 2.
  The Perspectives of Stem Cell-based Therapy in Neurological Diseases.- 3. Stem Cell-based Therapy for Lysosomal Storage Diseases.- 4. Drosophila germline stem cells.- 5. Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation.- 6. Cancer Stem Cells in Solid Tumors, Markers and Therapy.- 7. Cancer Stem Cells: Paradigm Shifting or Perishing Concept.- 8. Genomics of Prostate Cancer.- 9. Ischemia, reactive radicals, redox signaling and hematopoietic stem cells.- 10. Cancer stem cell models and role in drug discovery.- 11. Origins of Metastasis-Initiating Cells.- 12. The Reduction of Callus Formation during Bone Regeneration by BMP-2 and Human Adipose Derived Stem Cells.- 13. Stem cells and leukemia.- 14. The role of adult bone marrow derived mesenchymal stem cells, growth factors and scaffolds in the repair of cartilage and bone.- 15. Worth the Weight: Adipose Stem Cells in Human Disease.- 16. Neural crest and Hirschsprung's disease.- 17. Common denominators of self-renewal and malignancy IN neural stem cells and GLIOMA.- 18. Stem-like cells from brain tumours or vice versa?.- 19. Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics.- 20. Breast Cancer Stem Cells.- 21. Translin/TRAX deficiency affects mesenchymal differentiation programs and induces bone marrow failure.- 22. Cancer therapies and Stem cells.- 23. Cancer Stem Cells and Head and Neck Squamous Cell Carcinomas.- 24. The Biology of Lung Cancer Stem Cells.- 25. Stem Cell Characters in Primary and Metastatic Tumour Establishment.- 26. Plasticity of Cancer Stem Cells.- 27. Cross talks among Notch, Wnt, and Hedgehog signaling pathways regulate stem cell characteristics.- 28. Global OMICs profiling and functional analysis of CD44+/CD24- stem-like cells in normal human breast tissue and breast cancer.- 29. Breast Cancer Stem Cells: Isolation,characterization and targeting.