Alternative Laboratory Models for Drug Discovery

Embryonic and larval Danio rerio (zebrafish) is increasingly used as a toxicological model to conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features high genetic homology to mammals, robust, phenotypes, high-throughput genetic and chemical screening have made it a powerful tool to evaluate in vivo toxicity. New methodologies of genome editing as CRISPR/Cas9; ZFN and TALEN make it a suitable model to perform studies to pair human genetic diseases as well. This review surveys recent studies employing zebrafish as experimental model, comparing it with other in vivo and in vitro models, presenting zebrafish as a potent vertebrate tool to evaluate drug toxicity and efficacy in order to facilitate more extensive, easy and comprehensive knowledge of new generation drugs.

Autorentext

Prof. Mahesh Bhanudas NarkhedeHe has 15 yrs of experience in Teaching and Research. He is the recipient RANK PROJECT for M Pharm in Pharmacology Research work by The TN Pharma Sciences Welfare Trust, Chennai in 2009. He has guided about 02 PG student projects. He has also guided more than 35 students of B.Pharm. He has filed 4 patents.