Biological Inorganic Chemistry

Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function, Second Edition, provides a comprehensive discussion of the biochemical aspects of metals in living systems. Beginning with an overview of metals and selected nonmetals in biology, the book then discusses the following concepts: basic coordination chemistry for biologists; structural and molecular biology for chemists; biological ligands for metal ions; intermediary metabolism and bioenergetics; and methods to study metals in biological systems. The book also covers metal assimilation pathways; transport, storage, and homeostasis of metal ions; sodium and potassium channels and pumps; magnesium phosphate metabolism and photoreceptors; calcium and cellular signaling; the catalytic role of several classes of mononuclear zinc enzymes; the biological chemistry of iron; and copper chemistry and biochemistry. In addition, the book discusses nickel and cobalt enzymes; manganese chemistry and biochemistry; molybdenum, tungsten, vanadium, and chromium; non-metals in biology; biomineralization; metals in the brain; metals and neurodegeneration; metals in medicine and metals as drugs; and metals in the environment.

Autorentext

Unite de Biochimie, Universite Catholique de Louvain, Louvain-la-Neuve, Belgium Prof. Crichton, originally from the UK, is well known in the inorganic biology community and is invited to speak at many international conferences. He has published 3 books in this area (others on biochemistry of iron and metal-based neruodegeneration) and has taught over 750 doctoral and post-doctoral students. The book contains an essential distillation of the knowledge and material he had used to teach and lecture over many years.

Klappentext

The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. This text, written by a biochemist, presents an introduction to this field.

Zusammenfassung

".a fine scholarly text written in a reader-friendly style to describe the various roles of metals in biological systems, human health, and the environment. It also considers the mechanisms and experimental methods for studying biological processes involving metals.I would highly recommend it to all interested biology, and biochemistry students and researchers." --Science Progress, vol 97, issue 1, 2014

".a fine scholarly text written in a reader-friendly style to describe the various roles of metals in biological systems, human health, and the environment.The material of the second edition of this book has been updated, and new chapters have been included.I would highly recommend it to all interested biology, and biochemistry students and researchers." --Science Progress, February 18, 2014

"Crichton.offers this detailed and extensively illustrated text on inorganic components of biochemistry. Three introductory chapters explain the basic importance of metals in biology and orient biologists to coordination chemistry and chemists to molecular biology, respectively. General features of metal function are covered, including common ligands, their role in metabolism, assimilation and transport, and methods of study." --Reference & Research Book News, December 2013

"At first blush, inorganic biochemistry might sound like an oxymoron, but that is not the case here.Crichton's book will be useful resource for students or researchers who want to understand the exciting world of inorganic biochemistry." --CHOICE, October 2012, Vol. 50, No. 02

"Robert Crichton has blended an element-centric approach to the subject with a biological thread that is engaging and helpful in exploring the topics in detail. The text is both accessible and detailed, but pitched at undergraduate level." --Chemistry World

Inhalt

1. An Overview of Metals and Selected Nonmetals in Biology2. Basic Coordination Chemistry for Biologists3. Structural and Molecular Biology for Chemists4. Biological Ligands for Metal Ions5. An Overview of Intermediary Metabolism and Bioenergetics6. Methods to Study Metals in Biological Systems7. Metal Assimilation Pathways8. Transport, Storage, and Homeostasis of Metal Ions9. Sodium and Potassium - Channels and Pumps10. Magnesium-Phosphate Metabolism and Photoreceptors11. Calcium - Cellular Signalling12. Zinc - Lewis Acid and Gene Regulator13. Iron14. Copper - Coping with Dioxygen15. Nickel and Cobalt16. Manganese - Oxygen Generation and Detoxification17. Molybdenum, Tungsten, Vanadium, and Chromium18. Non-metals in Biology19. Biomineralisation20. Metals in Brain21. Metals and Neurodegeneration22. Metals in Medicine and Metals as Drugs23. Metals in the Environment