C. elegans and Innate Immunity

The striking similarities between the innate defenses of vertebrates and invertebrates as well as the amenability of Caenorhabditis elegans for genetic analysis have made this free-living ground nematode a popular model system in the study of bacterial pathogenesis. Although genetic studies have brought new insights, showing the inducibility and pathogen-specificity of the immune response, there is still much to be discovered about the exact mechanisms underlying resistance to infection. In this study a different angle was adopted to study host pathogen interactions in C. elegans. Given the dynamic nature of an immune response, the proteome of C. elegans was investigated at four different time-points (24, 48, 72, 96 h) after infection with S. typhi, S. typhi Ty21a, C. sakazakii and E. coli OP50 using SDS PAGE as a preliminary step to detect variation in the whole protein content.

Autorentext

P.Srinivasan, M.Sc., PGADMD. He has attended 15 conferences at national and international level and have published 2 papers.He is currently doing research in Proteomics at Bundelkhand University,UP,India.M.Rajalakshmi, M.Sc.,PGADMD.,(PhD).,She has attended more than 10 conferences and is doing PUFA research at Bharathiyar University,TN,India.