CD137 Pathway: Immunology and Diseases

This book covers all aspects of CD137/4-1BB pathway research. This pathway is emerging as one of the most important targets for manipulation of immune responses for disease diagnosis and treatment. The book's author discovered the CD-137 and B7H1 molecules in 1999.

The most practical and clinical reasons for attempting to understand the immunology of infections and disease revolves around the CD137 and CD137/41BB receptor and ligand molecules. This book covers all aspects of CD137/4-1BB pathway research from microbiology, infectious disease, molecular biology, biochemistry, and genetics to immune responses and potential applications in the diagnosis and treatment of human diseases. These include cancers, autoimmune diseases, viral infection and transplantation rejection. This pathway is emerging as one of the most important targets for manipulation of immune responses for disease diagnosis and treatment. Dr. Chen discovered the CD-137 and B7H1 molecules in 1999. His lab recently identified and described a new member of the important B7 family of immune system costimulatory molecules.

CD 137 pathway is emerging as one for the most important targets for manipulation of immune responses for disease diagnosis and treatment

Klappentext

This comprehensive volume, written by experts in the field, covers nearly all aspects of ongoing research related to the CD137 pathway. Recent research has shown that the manipulation of CD137 pathway molecules is very promising in the treatment of cancer, viral infection, transplantation rejection and autoimmune diseases in experimental animal models. The volume includes research related to the identification and understanding of functional consequences of CD137 receptor and ligand molecules which represents a major effort in the field of immunology. CD137 Pathway: Immunology and Diseases is an ideal book for immunologists, microbiologists, cancer researchers, molecular biologists, biochemists, and pharmaceutical and biotechnology company scientists.

Inhalt
Genes, Transcripts and Proteins of CD137 Receptor and Ligand.- CD137 Signal Transduction.- Significance of Reverse Signal Transduction for the Biology of the CD137 Receptor/Ligand System.- CD137 Signal in the Regulation of Innate Immunity.- Regulation of T Cell-Dependent Humoral Immunity Through CD137 (4-1BB) Mediated Signals.- CD137 in the Regulation of T Cell Response to Antigen.- Autoimmune Diseases.- CD137/CD137 Ligand in Tumor and Viral Immunotherapy.