Cellular Endocrinology in Health and Disease

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells.

The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer.

Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts

Autorentext
Alfredo Ulloa-Aguirre, M.D., D.Sc. is senior scientist in the Research Center for Population Health at the National Institute of Public Health and Professor of the National University of Mexico (UNAM), where he heads the Research Support Network of the National Institutes of Health in Mexico City. He received hisgraduate training in internal medicine and reproductive endocrinology at the National Institute of Medical Sciences and Nutrition SZ and earned the Doctoral degree in Medical Sciences from the UNAM. He received postdoctoral training at the University of Pennsylvania, Philadelphia PA, and has been visiting scientist at the Oregon National Primate Resarch Center, OHSU, Beaverton OR, and the Institut National de la Recherche Agronomique, in Tours, France (Le Studium Scientist). He is currently a member of the Studium Consortium for Research and Training in Reproductive Sciences (sCORTS, Le Studium, Orléans, France). An internationally recognized physician-scientist, Dr Ulloa-Aguirre has developed programmes in both clinical and basic research. His laboratory focuses on the structure-function relationship of gonadotropins and gonadotropin receptors as well as on the gonadotropin-releasing hormone receptor, with particular emphasis on the factors and mechanisms that control intracellular trafficking of these receptors. He is the author or co-author of over 165 research publications and several book chapters.Dr. Ya-Xiong Tao is currently Professor of Physiology at Auburn University College of Veterinary Medicine in Auburn, Alabama, USA. He has been working on several G protein-coupled receptors, including gonadotropin receptors regulating reproduction, and melanocortin receptors regulating energy and glucose homeostasis. He has published extensively in peer-reviewed biomedical journals and obtained funding for his research from National Institutes of Health, American Diabetes Association and American Heart Association, among others. He has delivered numerous lectures at universities and research institutes in USA, Canada, China, India, and Mexico. He has edited ten volumes, including seven volumes in Progress in Molecular Biology and Translational Science. He teaches several courses, including Physiology, Receptorology, Genomics and Personalized Medicine, and Molecular Endocrinology, for veterinarian, graduate, and undergraduate Honors students.

Klappentext
Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells.

The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer.

Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts

Inhalt

1. Thyroid hormone receptors and their role in cell proliferation and cancer"
   
   2. The molecular cell biology of anterior pituitary cells
   3. Sensing calcium levels -the biology of the parathyroid cell
   4. The biology of pituitary stem cells
   5. The Na(+)/I(-) symporter and biosynthesis of thyroid hormones
   6. The FSH signaling network in Sertoli cells
   7. Epigenetics and pituitary cell growth
   8. Epigenetics and metabolic abnormalities
   9. Unraveling the mechanisms underlying GnRH pulse generation: test of the proposed role for KNDy neurons
   10. Proteomics and Cellular Signaling
   11. Transcriptome analysis of adrenocortical cells in health and disease
   12. Bone as an endocrine organ
   13. The control of steroidogenesis of adrenocortical cells
   14. The adipocyte as endocrine target
   15. Insulin secreting cell lines: potential for research and diabetes therapy
   16. The architecture of human pancreatic islets as revealed by molecular imaging
   17. Computational models to decipher cell signaling pathways
   18. The regulation of theca cell-granulosa cell dialogue by endocrine and paracrine factors
   19. Unraveling the mechanism of action of the GnRH pulse generator: the TAC3/TAC3R-dinorphin-Kiss1/Kiss1R neuronal connection
   20. Endocrinology of the single cell
   21. Altering aberrant intracellular trafficking of cell surface membrane receptors by pharmacological chaperones
   22. Deiodinases: taylors that suit intracellular thyronine demands
   23. Micro RNAs and non-coding RNAs in beta-cell function