Computational Drug Designing of MraY in Pathogenic Atherosclerosis

Atherosclerosis is a multifactorial vascular inflammatory disease which is one of top most common cause of deaths around worldwide. Implementing Bioinformatics tools, phospho-MurNAc-pentapeptide translocase (MraY) was identified as one of the crucial drug targets against eleven pathogens causing atherosclerosis. MraY is an essential enzyme membrane which plays a crucial role in catalyzing the essential step of bacterial cell wall biosynthesis in Gram-negative bacteria. The enzyme MraY mainly involves in the peptidoglycan biosynthesis which is unique and important for the survival of pathogens. Therefore, by blocking MraY function with lead 1 would dissolve the structural integrity, flexibility and rigidity of the cell wall and expose the pathogens to osmotic lysis and hinders the proliferation of eleven pathogens causing atherosclerosis. Hence, lead 1 will provide a framework for developing new antagonists against the eleven pathogens causing atherosclerosis.

Autorentext

MSc (Gold Medalist) & PhD Bioinformatics, no Sri Venkateswara Institute of Medical Sciences (SVIMS) Tirupati, trabalhou como estagiário da DBT, DST-INSPIRE Jr & Sr Research Fellow com 51 artigos/abstracts de investigação publicados em revistas/conferências nacionais e internacionais. Premiado com 8 melhores trabalhos/poster. Actualmente a trabalhar como Cientista no ICGEB, Delhi.