Death Receptors and Cognate Ligands in Cancer

Death receptors play a central role in directing apoptosis in mammalian cells. This book explores the molecular basis of death receptor signaling and their role in cancer development.

Inhalt
The Role of TNF in Cancer.- Many Checkpoints on the Road to Cell Death:Regulation of FasFasL Interactions and Fas Signaling in Peripheral Immune Responses.- FasL Expression and Reverse Signalling.- Impact of TNF-R1 and CD95 Internalization on Apoptotic and Antiapoptotic Signaling.- Ubiquitination and TNFR1 Signaling.- From Biochemical Principles of Apoptosis Induction by TRAIL to Application in Tumour Therapy.- Therapeutic Targeting of TWEAK/Fn14 in Cancer: Exploiting the Intrinsic Tumor Cell Killing Capacity of the Pathway.- APRIL in B-cell Malignancies and Autoimmunity.- Autophagy in Cancer and Chemotherapy.- Glucocorticoid-Mediated Apoptosis Resistance of Solid Tumors.- Targeting Death-Receptors in Radiation Therapy.- Death Ligands Designed to Kill: Development and Application of Targeted Cancer Therapeutics Based on Proapoptotic TNF Family Ligands.