Design Automation Methods and Tools for Microfluidics-Based Biochips

Microfluidics-based biochips, also known as lab-on-a-chip or bio-MEMS, are becoming increasingly popular for DNA analysis, clinical diagnostics, and the detection/manipulation of bio-molecules. As the use of microfluidics-based biochips increases, their complexity is expected to become significant due to the need for multiple and concurrent assays on the chip, as well as more sophisticated control mechanisms for resource management. Time-to-market and fault tolerance are also expected to emerge as design considerations. As a result, current full-custom design techniques will not scale well for larger designs. There is a need to deliver the same level of CAD support to the biochip designer that the semiconductor industry now takes for granted.

Design Automation Methods and Tools for Microfluidics-Based Biochips deals with all aspects of design automation for microfluidics-based biochips. Experts have contributed chapters on various aspects of biochip design automation. Topics include device modeling; adaptation of bioassays for on-chip implementations; numerical methods and simulation tools; architectural synthesis, scheduling and binding of assay operations; physical design and module placement; fault modeling and testing; reconfiguration methods.

A complete volume that includes chapters contributed by the world's leading experts in microfluidics and CAD for biochips The first edited volume that addresses all aspects of biochip design automation technology issues, modelling and simulation, synthesis, layout, and data analysis Bridges different research communities MEMS, fluidics, design automation, biochemistry, etc. Balanced treatment of theory and applications to practical problems

Inhalt
MICROFLUIDICS-BASED BIOCHIPS: TECHNOLOGY ISSUES, IMPLEMENTATION PLATFORMS, AND DESIGN AUTOMATION CHALLENGES.- MODELING AND SIMULATION OF ELECTRIFIED DROPLETS AND ITS APPLICATION TO COMPUTER-AIDED DESIGN OF DIGITAL MICROFLUIDICS.- MODELING, SIMULATION AND OPTIMIZATION OF ELECTROWETTING.- ALGORITHMS IN FASTSTOKES AND ITS APPLICATION TO MICROMACHINED DEVICE SIMULATION.- COMPOSABLE BEHAVIORAL MODELS AND SCHEMATIC-BASED SIMULATION OF ELECTROKINETIC LAB-ON-A-CHIP SYSTEMS.- FFTSVD: A FAST MULTISCALE BOUNDARY ELEMENT METHOD SOLVER SUITABLE FOR BIO-MEMS AND BIOMOLECULE SIMULATION.- MACROMODEL GENERATION FOR BIOMEMS COMPONENTS USING A STABILIZED BALANCED TRUNCATION PLUS TRAJECTORY PIECEWISE LINEAR APPROACH.- SYSTEM-LEVEL SIMULATION OF FLOW INDUCED DISPERSION IN LAB-ON-A-CHIP SYSTEMS.- MICROFLUIDIC INJECTOR MODELS BASED ON ARTIFICIAL NEURAL NETWORKS.- COMPUTER-AIDED OPTIMIZATION OF DNA ARRAY DESIGN AND MANUFACTURING.- SYNTHESIS OF MULTIPLEXED BIOFLUIDIC MICROCHIPS.- MODELING AND CONTROLLING PARALLEL TASKS IN DROPLET-BASED MICROFLUIDIC SYSTEMS.- PERFORMANCE CHARACTERIZATION OF A RECONFIGURABLE PLANAR ARRAY DIGITAL MICROFLUIDIC SYSTEM.- A PATTERN-MINING METHOD FOR HIGH-THROUGHPUT LAB-ON-A-CHIP DATA ANALYSIS.