Enantiopure biologically active compounds by lipase catalysis

For several years enzymes and whole cells have been used as catalysts both in Academia and Industry. Such catalysts are now used in research for renewable energy and for production of fine chemicals. Enzymes are used in organic chemistry in particular for their ability to catalyse reactions stereoselctively. In order to create enantiopure building blocks for synthesis of biologically active compounds Dr. Jacobsen has used lipase for kinetic resolution. This book covers the significance of chirality for biological action, principles of of enzyme catalysis and in particular the use of enzyme catalysis for kinetic resolution and asymmetrization.

Autorentext

Elisabeth Jacobsen started her chemistry carreer in Norwegian Cosmetic Industry.She obtained her PhD in organic chemistry in 2004 from the Norwegian University of Science and Technology, where she became an associate professor in 2005. Her research focusses on synthesis of enantiopure biologically active compounds by biocatalysis.