Endocrine Disruption and Human Health

Selected for Doody s Core Titles® 2024 in Endocrinology/Metabolic Disease

Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered.

With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students.

Autorentext
Professor Philippa Darbre is Professor Emeritus in Oncology in the School of Biological Sciences at the University of Reading in the UK. She is an academic scientist who has been carrying out research into estrogen action in breast cancer for over 40 years and has been investigating the role of estrogen-mimicking chemicals since before the term endocrine disruption” came into being in the early 1990s. She trained as a biochemist and holds the degrees of BScHons from the University of Birmingham, UK (1973) and PhD from the University of Cambridge, UK (1977). Her postdoctoral research began at the Molecular Medicine Institute at the University of Oxford where she held the first Nuffield Medical Research Fellowship of the University of Oxford and a Junior Research Fellowship at St Hugh's College. In 1981, she moved to the Imperial Cancer Research Fund laboratories in central London (now Cancer Research UK) where she became Head of the Cellular Endocrinology Laboratory. In 1991, she moved to the University of Reading and retired to Emeritus status in 2017. From retirement, she continues research into the role of endocrine disrupting chemicals in breast cancer together with some teaching of undergraduates in endocrinology and cancer. She continues to serve on the editorial board of the Journal of Applied Toxicology, is patron of the charity Canceractive” and is a member of the science panel of the charity, BreastCancer UK. She has written two books on molecular biology methods, has guest-edited a previous journal volume on endocrine disrupters, has published 150 peer-reviewed research papers, and served as founding editor of the first edition of the book, Endocrine Disruption and Human Health.

Klappentext

Selected for Doody’s Core Titles® 2024 in Endocrinology/Metabolic Disease

Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered.

With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students.

Inhalt

SECTION 1 OVERVIEW and SCOPE
1. What is endocrine disruption?

2. Which chemicals are endocrine disruptors?

   SECTION 2 MECHANISMS and ASSAY SYSTEMS
   3. Environmental oestrogens: Disrupters of oestrogen action

3. Disrupters of androgen action
4. Assay systems for studying endocrine disruption
5. Non-monotonic responses in endocrine disruption

6. Endocrine disrupters as modifiers of endogenous hormone synthesis

   SECTION 3 CONCERNS FOR HUMAN HEALTH
   8. Endocrine disruption and female reproductive health

7. Endocrine disruption and breast cancer
8. Endocrine disruption and male reproductive health
9. Endocrine disruption and prostate cancer
10. Endocrine disruption and thyroid disease
11. Endocrine disruption of adrenal function
12. Endocrine disruption of developmental pathways and children's health
13. Endocrine disruption of immune function
14. Endocrine disruption and obesity, metabolic syndrome and type 2 diabetes
15. Endocrine disruption and cardiovascular disease
16. Transgenerational effects of endocrine disruption
17. Regulatory considerations