Experimental Metastasis: Modeling and Analysis

Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination. Each chapter is introduced by short discussion of clinical aspects of certain metastatic pathway. Especial attention is paid for methods of visualization, quantification and analysis of the modeled metastases. Additional chapter is devoted to methods of mathematic modeling of tumor spread. The data presented in the book may be helpful for cancer researchers and oncologists.

Structure of the book is based on anatomical areas of cancer dissemination that has clinical relevance Any chapter is written/supervised by leading researcher in specific area of metastasis research The book is focused on experimental approach of metastatic cancer research: any chapter contains supportive theoretical information and detailed description of relevant laboratory procedures The book is supplemented by informative illustrations, schemes and tables Extensive lists of references for any chapter provides with possibility of effective deep study Includes supplementary material: sn.pub/extras

Klappentext

Metastatic dissemination remains a main cause for cancer related deaths. Investigation of the molecular mechanisms of the metastatic process presents an important area of cancer research and may provide clinical oncologists with new methods to prevent and manage cancer dissemination.

Availability of adequate experimental models is an essential requirement of the productive investigation. Over the many years of cancer research, plenty of model systems (in vitro and in vivo) were created to reproduce certain steps or to estimate certain aspects of metastatic process. Currently right selection and correct application of the experimental models as well as analytic technique may present a challenge.

This book provide with guideline information about experimental modelling and analysis of the metastatic process. The structure of the book reflects clinical aspects: pathway and area of the metastatic dissemination. Thus, first part of book is devoted to local, mainly via lymph system, spread of head and neck, breast and pancreatic cancers. Second part is about distant, via blood stream, dissemination into brain and lung (most often sites of metastatic lesion regardless the primary tumour issue). Third part includes chapter describing methods of modelling and study specific metastatic pathways: via portal vein system and through serous cavities. Any chapter is introduced by short review of clinical/biological aspects of the specific metastatic process, provides with description of relevant laboratory techniques, supplemented with representative illustrations and extended references list. Theoretic aspects of cancer dissemination and mathematic approaches to model metastatic spread of tumour are reviewed in the last chapter.

Chapters ofthe book are written by leading specialists in certain areas of metastatic cancer research, therefore the book presents a comprehensive guide for researchers and may be helpful for clinical oncologists.

Inhalt
Preface.- Introduction.- Head and neck cancer.- Breast cancer invasion and metastasis.- Mouse models of pancreatic cancer.- Brain Metastasis.- Lung metastasis.- Liver Metastases.- Malignant pleural effusion.- Mathematic modeling of metastatic process. Index.