Focus on Extrapyramidal Dysfunction

Experts in the fields of neurology, neuroscience, neurobiology and psychiatry review and present novel findings of basic and clinical research on extrapyramidal disorders and allied conditions. New insights on the nature of extrapyramidal dysfunction and its therapy in the fields of neurology, psychiatry and neuroscience are presented.

comprehensive presentation of basic and clinical research on extrapyramidal dysfunction • new therapeutic principles in extrapyramidal disorders • novel findings in Parkinson's disease, Huntington's disease and allied conditions

Inhalt
Dopaminergic neurotoxicity of homocysteine and its derivatives in primary mesencephalic cultures.- MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease.- Screening for mutations in synaptotagmin XI in Parkinson's disease.- Depletion and restoration of endogenous monoamines affects ?-CIT binding to serotonin but not dopamine transporters in non-human primates.- Differential executive control impairments in early Parkinson's disease.- Simple movement sequences better correlate to levodopa plasma levels than complex ones.- Clinical effects of repetitive transcranial magnetic stimulation versus acute levodopa challenge.- Impact of apomorphine on BOLD signal during movement in normals.- Worsened motor test performance following acute apomorphine injection in previously untreated patients with Parkinson's disease.- Transdermal lisuride delivery in the treatment of Parkinson's disease.- Congruent deterioration of complex and simple movements in patients with Huntington's disease.- Methyltetrahydrofolate reductase polymorphism influences onset of Huntington's disease.- Coenzyme Q10 serum levels in Huntington's disease.- The N-methyl-D-aspartate antagonist memantine retards progression of Huntington's disease.- Transcranial sonography in spinocerebellar ataxia type 3.- Therapeutic strategies in Friedreich's ataxia.- Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder.