Fundamentals of Forensic DNA Typing

Explains the DNA analysis process beginning with collection of evidence at a crime scene to the statistical interpretation of the results. This book details genetic genealogy and tracing domestic pet hairs to perpetrators. It includes a glossary with over 400 terms for reference of unfamiliar terms and an acronym guide to decipher the DNA dialect.

Autorentext
John M. Butler is a NIST Fellow and Special Assistant to the Director for Forensic Science, Office of Special Programs, at the U.S. National Institute of Standards and Technology, in Gaithersburg, Maryland. Dr. Butler earned his PhD from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He has won numerous scientific awards, including being named Science Watch's #1 world-wide high-impact author in legal medicine and forensic science over the last decade (July 2011). He has over 150 publications in this field and is a frequent presenter on the topic of DNA typing, and has authored four other DNA Typing books including Advanced Topics in Forensic DNA Typing: Methodology. For a detailed CV, visit http://www.cstl.nist.gov/strbase/butler.htm.

Klappentext

The success of the previous editions of Forensic DNA Typing has created an overwhelming demand for an introductory level textbook on the subject. Fundamentals of Forensic DNA Typing satisfies this need by providing a basic textbook to aid students in gaining an introductory understanding of forensic DNA testing. The basic text will contain simpler "starter" information, while incorporating popular elements of Forensic DNA Typing such as the Data, Notes and Applications (D.N.A.) Boxes that are expanded on to bring perspective and purpose to the topics covered in each chapter. In addition, the pros and cons of the currently controversial technique of familial searching will be explored. With its clear and understandable style and extensive list of online ancillaries and study aids, this textbook will make the subject accessible to students in forensic science courses worldwide.

Inhalt

Foreword
Introduction
Acknowledgments
About the author

1 Overview and History of DNA Typing
2 Basics of DNA Biology and Genetics
3 Historical Methods
4 Sample Collection, Storage and Characterization
5 DNA Extraction
6 DNA Quantitation
7 DNA Amplification (The Polymerase Chain Reaction)
8 Short Tandem Repeat Markers
9 Fundamentals of DNA separation and Detection
10 STR Genotyping and Data Interpretation
11 Statistical Interpretation: Evaluating the Strength of Forensic DNA Evidence
12 DNA databases
13 Quality Assurance
14 Forensic Challenges: Degraded DNA, Mixtures, and LCN
15 Additional Loci and Non-Human DNA Testing
16 Lineage Markers: Y Chromosome and mtDNA Testing
17 Applications of DNA Typing
18 Future Trends

Appendix
1 Glossary of Terms
2 Useful Websites
3 Probability and Statistics