Handbook of the Biology of Aging

*Handbook of the Biology of Aging, Eighth Edition,* provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems.

The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.

Autorentext
Dr. Nicolas Musi is a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and the San Antonio Geriatric Research, Education and Clinical Center. He is an active educator and research mentor, and supervises clinical and research fellows, residents and graduate students. In this role, he also functions as Director of a T32 Training Grant on the Biology of Aging. Dr. Peter Hornsby obtained a Ph.D. in Cell Biology at the Institute of Cancer Research of the University of London. He has held faculty positions at the University of California SanDiego, the Medical College of Georgia, and Baylor College of Medicine. Currently he is Professor in Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio.

Klappentext
Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems.

The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.

Inhalt

Foreword
Preface

Section I: Basic Mechanisms of Aging: Models and Systems

Chapter 1 - Longevity as a Complex Genetic Trait
George L. Sutphin and Ron Korstanje

Chapter 2 - The mTOR Pathway and Aging
Katherine H. Schreiber, Monique N. O'Leary, and Brian K. Kennedy

Chapter 3 - Sirtuins, Healthspan, and Longevity in Mammals
William Giblin and David B. Lombard

Chapter 4 - The Hypoxic Response and Aging
Scott F. Leiser, Hillary A. Miller, and Matt Kaeberlein

Chapter 5 - The Role of Neurosensory Systems in the Modulation of Aging
Michael J. Waterson and Scott D. Pletcher

Chapter 6 - The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan
Kaitlyn N. Lewis and Rochelle Buffenstein

Chapter 7 - Contributions of Telomere Biology to Human Age-Related Disease
Ting-Lin B. Yang, Shufei Song, and F. Brad Johnson

Chapter 8 - Systems Approaches to Understanding Aging
Lei Hou, Dan Wang, Hao Cheng, Bo Xian, and Jing-Dong J. Han

Chapter 9 - Integrative Genomics of Aging
João Pedro de Magalhães and Robi Tacutu

Chapter 10 - NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging
Nancy L. Nadon, Richard A. Miller, Randy Strong, and David E. Harrison

Chapter 11 - Comparative Biology of Aging: Insights from Long-Lived Rodent Species
Michael Van Meter, Vera Gorbunova, and Andrei Seluanov

Section II: The Pathobiology of Human Aging

Chapter 12 - Genetics of Human Aging
Miook Cho and Yousin Suh

Chapter 13 - The Aging Arterial Wall
Mingyi Wang, Robert E. Monticone, and Edward G. Lakatta

Chapter 14 - Age-Related Alterations in Neural Plasticity
Shannon J. Moore and Geoffrey G. Murphy

Chapter 15 - The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention
Ludmila Müller and Graham Pawelec

Chapter 16 - Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms
Ingrid A. Harten, Michelle Olive, and Thomas N. Wight

Chapter 17 - Cardiac Aging
Dao-Fu Dai, Ying-Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, and Peter S. Rabinovitch

Chapter 18 - Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity
Eileen M. Cr4immins and Morgan E. Levine

Chapter 19 - On the Compression of Morbidity: From 1980 to 2015 and Beyond
James F. Fries