Handbook on Analyzing Human Genetic Data

This handbook offers professionals and researchers guidance on the selection of appropriate computational methods and software packages for specific genetic problems. The coverage features both methodological expositions and practical guidelines.

This handbook provides human geneticists and other biomedical researchers with guidance on selections of appropriate computational methods and software packages for their specific genetic problems. It may also be used by students and other learners as a reference in conjunction with a more theoretical and/or methodologically oriented text book. Coverage strikes a balance between methodological expositions and practical guidelines for software selections. Wherever possible, comparisons among competing methods and software are made to highlight the relative advantages and disadvantage of the approaches so that readers can make informed choices to best match their specific needs.

Focus on computational methods and associated software Competing methods and software are compared and relative advantages and disadvantages highlighted Helps to select the appropriate methods for a particular genetic problem Includes supplementary material: sn.pub/extras

Inhalt
Population Genetics.- Haplotype Structure.- Linkage Analysis of Qualitative Traits.- Linkage Analysis of Quantitative Traits.- Markov Chain Monte Carlo Linkage Analysis Methods.- Population-Based Association Studies.- Family-Based Association Studies.- Haplotype Association Analysis.- Multiple Comparisons/Testing Issues.- Estimating the Absolute Risk of Disease Associated with Identified Mutations.- Processing Large-Scale, High-Dimension Genetic and Gene Expression Data.