History, importance, and some basic concept of chirality

Chiral drugs are currently 50% used and near 90% of the last ones are marketed as racemates consisting of an equimolar mixture of two enantiomers. While they have the same scaffold, but they shows different biological activities such as pharmacology, toxicology, pharmacokinetics, metabolism etc. Therefore, it is significant to endorse the chiral separation and analysis of racemic drugs either in industry or in the clinic so as to eliminate the unwanted isomer from the groundwork and to find an optimal treatment and a right therapeutic control for the patient. In this article, we have briefly discussed the history of chirality, importance, and some basic concept of them. We have also included the importance of separation and various resolution methods.

Autorentext

Manoj N. Bhoi was obtained his M.Sc. degree in organic chemistry in 2012 both from the Gujarat University, Ahmedabad (India). Currently, he is pursuing his Ph.D. under the guidance of Dr. Hitesh D. Patel at the Chemistry Department of the Gujarat University, Ahmedabad. His research focuses on multicomponent reactions and asymmetric synthesis.