Hormone Therapy and Castration Resistance of Prostate Cancer

Elucidates the current status of hormone therapy for prostate cancer

Clarifies the differences between the evidence from Japan and that from Western countries on hormone therapy for prostate cancer

Broadens the reader's understanding of castration-resistant prostate cancer

Elucidates the current status of hormone therapy for prostate cancer Clarifies the differences between the evidence from Japan and that from Western countries on hormone therapy for prostate cancer Broadens the reader's understanding of castration-resistant prostate cancer

Autorentext

Dr. Yoichi Arai,

Professor and Chairman,

Department of Urology,

Tohoku University School of Medicine

Dr. Osamu Ogawa,

Professor and Chairman,

Department of Urology,

Kyoto University Graduate School of Medicine

Inhalt

1. Introduction.- 2. Recent trends in hormone therapy for prostate cancer in Japan.- 3. Risk assessment among patients receiving primary ADT.- 4. Patient-derived xenografts for research on hormonal therapy of prostate cancer.- 5. Impact of GnRH antagonist and LHRH agonist on the gonadal axis.- 6. Controversies on complete androgen blockade.- 7. Adrenal androgen in prostate cancer.- 8. Intermittent ADT for prostate cancer.- 9. Pognostic significance of monitoring serum testosterone in primary ADT.- 10. Ethnic variation in clinical outcomes of primary ADT for prostate cancer.- 11. ADT in combination with radical prostatectomy.- 12. ADT in combination with radiation therapy.- 13. ADT as salvage therapy after definitive treatment.- 14. ADT for clinically localised prostate cancer.- 15. Complications of ADT.- 16. Hot flash.- 17. Oseteoporosis and fracture risk.- 18. Metaboplic change.- 19. Bone scan index as a biomarker of bone metastasis.- 20. Genetic polymorphism analysis in predictingprognosis of metastatic prostate cancer.- 21. Local therapy in combination with ADT for metastatic prostate cancer.- 22. Oxidative stress and CRPC.- 23. Alternative antiandrogen therapy for CRPC.- 24. Optimization of sequential AR targeted therapy for CRPC.- 25. Enzalutamide therapy for mCRPC in Japanese men.- 26. Abiraterone acetate therapy for mCRPC in Japanese men.- 27. Role of estramustine phosphate for CRPC.- 28. Steroid therapy for CRPC.- 29. MicroRNA analysis in prostate cancer.- 30. AR splicing variant in prostate cancer.- 31. Detection of CTC in CRPC.- 32. New biomarker for CRPC: Glycobiologic perspective.- 33. Bone-tageted treatment in CRPC management.- 34. Skeletal complications in CRPC patients.- 35. Urological complications in men dying from prostate cancer.- 36. Prediction of optimal docetaxel regimen for patients with mCRPC.- 37. Intermittent chemotherapy with decetaxel for mCRPC.- 38. Chemotherapy with cabazitaxel for CRPC in Japanese men.- 39. New tageted approach toCRPC.- 40. Molecular basis of neuroendocrine prostate cancer.- 41. Gene therapy for prostate cancer.- 42. Immune therapy for CRPC.- 43. New approach to CRPC using inactivated virus.- 44. Patient-reported outcome in the management of CRPC.