Leukocyte Adhesion Molecules

Leukocyte adhesion molecules promise to be highly effective as antigens in the antibody-directed leucocyte elimination treatment prior to grafting or in cases of acute and chronic inflammatory disease. This comprehensive review of contemporary research provides thorough discussions of the structure of these molecules, their in vitro function, and the role that they play in vivo as evidenced by results shown in inflammatory models where antibodies against these molecules are given to inhibit their function. The blend of basic science and clinical applications provides clear evidence of the biological relevance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion.

Inhalt
1 Structure and Function of the Integrin Family.- 1 Leukocyte Integrins.- 2 Structure and Functions for the Adhesion Receptors VLA-2 and VLA-4: Comparisons to other Members of the Integrin Superfamily.- 3 Fibronectin Receptor Expression on Thymocytes.- 4 Mechanism Regulating Recruitment of CDllb/CD18 to the Cell Surface is Distinct From That Which Induces Adhesion in Homotypic Neutrophil Aggregation.- 2 Adhesion in Disease and Therapy.- 5 Mechanisms of Neutrophil Emigration.- 6 Leukocyte Adhesion Deficiency as a Model for the Study of the Functional Role of LFA-1.- 7 Role of Cellular Adhesion in Inflammatory Cutaneous Disorders.- 8 Characterization of a New Mobilizable Mac-1 (CD11b/ CD18) Pool That Co-Localizes with Gelatinase in Human Neutrophils.- 9 Anti-Inflammatory Properties of Monoclonal Anti-Mo1 (CDllb/CD18) Antibodies In Vitro and In Vivo.- 10 CDwl8 Dependent Adhesion of Leukocytes to Endothelium and Its Relevance for Cardiac Reperfusion.- 11 Role of Anti-Adhesion Monoclonal Antibodies in Rabbit Lung Inflammation.- 3 Myeloid Cell Adhesion.- 12 The Role of LFA-1 and Related Antigens in Adhesion-Mediated Functions of Human Monocytes.- 13 Role of ICAM-1 in the Adherence of Human Neutrophils to Human Endothelial Cells In Vitro.- 14 Specificity and Regulation of CD18-Dependent Adhesions.- 15 CD18 Dependence of Primate Eosinophil Adherence In Vitro.- 16 Identification and Characterization of Endothelial-Leukocyte Adhesion Molecule 1.- 4 Lymphocyte Adhesion.- 17 Homing Receptors in Lymphocyte, Neutrophil, and Monocyte Interaction with Endothelial Cells.- 18 Antigen-Independent Adhesion: A Critical Process in Human Cytotoxic T Cell Recognition.- 19 Inhibition of Human Mixed Lymphocyte Reactions by Monoclonal Antibodies to Intercellular Adhesion Molecule-1 (ICAM-1).- 20Lymphocyte Function-Associated Antigen-1 (LFA-1) is a Signaling Molecule for Human T Lymphocytes.- 21 Involvement of Lymphocyte Function-Associated Antigen-1 and Intercellular Adhesion Molecule-1 in Monocyte and T-Cell Antigen-Specific Interactions.- 22 Immunosuppression of Cynomolgus Recipients of Renal Allografts by R6.5, a Monoclonal Antibody to Intercellular Adhesion Molecule-1.