Lipophilic drugs(Statins)and cardiovascular diseases in albino rats

In this study, the physiological and molecular effects of two cholesterol lowering agents , synthetic statin (atorvastatin) and natural statin (simvastatin) on diabetic and hypercholesterolemic adult male Wistar albino rats (Rattus norvegicus)at two doses, 10 and 40 mg/kg, for 8 weeks was investigated. Other physiological parameters were evaluated under this investigation, like: glucose, urea, uric acid, creatinine, total protein, albumin, globulin, A/G ratio, total, direct and indirect billirubin) To assess the beneficial effect of the drugs on liver genomic DNA, the (RE) analysis with 5 restriction endonucleases manifested variations in DNA digestion patterns in diabetic and hypercholesterolemic rats treated with atorvastatin and simavstatin. Such variation reflects and clarifies a restoration and repairing effect of statin on rat liver DNA in diabetic and hypercholesterolemic rats.

Autorentext

Prof. Mohamed Salama, Prof.Salwa Kamal, Dr.Dalia Abdel-Badeeh and Dr. Haytham Badrawy are a research team from the Department of Entomology, Faculty of Science, Ain Shams University, Cairo, Egypt. They are working in the field of molecular insect taxonomy. This study is the research work of the Ph.D. work of Dr.Haytham Badrawy Mosa