Magnetic Resonance Spectroscopy: An Insight in CellFocal Adhesions

Focal Adhesion (FA) plays a central role in cellattachment and migration; it controls embryogenesis,tissue repair, inflammatory response and tumorinvasion. Cell migrates through the regulatedalternative assembly and disassembly of FocalAdhesion. It pulls the cell body forward by grabbingand releasing Extra-Cellular Matrix (ECM). For itsimportance, the mechanism of FA controlling has beena major research focus during the past 10 years.However, the fundamental question of how the FAassembly and disassembly are precisely controlledremains unanswered. PAK, FAK, Paxillin and GIT1 areimportant structural and signaling components in FA.To answer the critical question in the field of celladhesion and migration, Nuclear Magnetic Resonance(NMR) Spectroscopy is used to study the structuresand regulations between these proteins. This bookfocuses on the structural and functional study ofGIT1 and discusses the Focal Adhesion control throughsome novel discoveries. For the first time, thiswork has consolidated existing evidences, includingsome controversial findings, to provide an excitingworking model on the FA regulation.

Autorentext

Ziwei Matt Zhang, MD., PhD., Studied Clinic Medicine at the Fudan University; and Molecular Biology at the University of Tennessee. His Main Interests are the Application of Magnetic Resonance Spectroscopy and Imaging in the Study of Childhood Cancers. Currently a Research MRI Specialist at St. Jude Children's Research Hospital, Memphis, TN, USA.

Klappentext
Focal Adhesion (FA) plays a central role in cell attachment and migration; it controls embryogenesis, tissue repair, inflammatory response and tumor invasion. Cell migrates through the regulated alternative assembly and disassembly of Focal Adhesion. It pulls the cell body forward by grabbing and releasing Extra-Cellular Matrix (ECM). For its importance, the mechanism of FA controlling has been a major research focus during the past 10 years. However, the fundamental question of how the FA assembly and disassembly are precisely controlled remains unanswered. PAK, FAK, Paxillin and GIT1 are important structural and signaling components in FA. To answer the critical question in the field of cell adhesion and migration, Nuclear Magnetic Resonance (NMR) Spectroscopy is used to study the structures and regulations between these proteins. This book focuses on the structural and functional study of GIT1 and discusses the Focal Adhesion control through some novel discoveries. For the first time, this work has consolidated existing evidences, including some controversial findings, to provide an exciting working model on the FA regulation.