Molecular Signaling and Regulation in Glial Cells

The present book deals with cellular and molecular interactions between nerve and glial cells, which are of basic importance for a proper functioning of the nervous system.

Inhalt
1 Signaling for Glial Cells.- Cytokines, Growth Factors and Their Intracellular Cascades.- Origins and early development of oligodendrocyte precursor cells.- Cytokine and growth factor synthesis in human astrocytes.- Mature pig astrocytes do not respond to NGF as oligodendrocytes do.- Endopeptidase-24.11/common acute lymphoblastic leukemia antigen CD 10 in Schwann cells: evidence for a role in nerve development and regeneration.- Regulation of oligodendrocyte development by the LIF cytokine subfamily: studies of the neonatal lineage cultured from rat cerebrum.- HlV-1 Env and glutamate induction of NO, IL1, and TNF.- Proteinkinase C stimulation induces astrocyte and oligodendrocyte proliferation, demyelination and enhanced remyelination in aggregating rat brain cell cultures.- Monosialogangliosides and nerve growth factor stimulate synthesis of glycoproteins in glioma cells.- Ion Channels and Neurotransmitter Receptors.- Responses of oligodendrocytes to classical neurotransmitters: signaling pathways.- Ion channel expression and function in astrocytic scars.- Ion channel expression in glial cells from trout CNS.- Ion channel reorganization during remyelination.- Gap junction expression in myelinating cells.- 2 Genes and Proteins of Myelin.- Structure, Regulation and Function.- CNS myelination: What can we learn from phylogeny?.- The proteolipid protein gene family in the central nervous system of fish.- Molecular structure of myelin genes in the CNS of trout.- Transcriptional controls in the oligodendrocyte lineage.- Regulation of MBP mRNA translocation in oligodendrocytes.- Molecular cloning of new basic helix-loop-helix proteins from the mammalian central nervous system.- 3 Neural Repair Mechanisms in the CNS.- Cellular Responses to Injury.- Microglial and astroglial activation patterns in neural graft rejection and neuronal and axonal degeneration.- The effect of myelin disruption on spinal cord regeneration.- Does myelin inhibit regeneration and remyelination ?.- Aspects of remyelination by endogenous and transplanted glial cells in regenerating goldfish visual system.- Remyelination of Lesions in Multiple Sclerosis.- Patterns of demyelination in multiple sclerosis as defined by oligodendrocyte pathology.- The adult human oligodendrocyte progenitor.- Strategies to promote CNS remyelination in vivo.- Immunomodulatory therapy of multiple sclerosis: current trials and future perspectives.- Cell Transplantation.- Identification of new cell surface receptors on oligodendrocyte lineage cells.- Transplantation of oligodendrocyte progenitors and CG4 cells into the developing rat brain: Differences and similarities.- OLN-cells: A new oligodendroglia cell line with impact for cell transplantation.- Schwann cell suspension grafts promote reconstruction of transected postcommissural fornix in the adult rat.- The biology of the transplanted oligodendrocyte progenitor.