Mouse Models of Vascular Diseases

This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.

Illustrates the entire process of establishing original mice models Covers a wide range of vascular diseases Provides readers with a strong tool for basic research on cardiovascular diseases and metabolic disorders Includes supplementary material: sn.pub/extras

Autorentext
Masataka Sata, MD, PhD: Institute of Biomedical Sciences, Department of Cardiovascular Medicine, Tokushima University.

Inhalt

Part IRe-stenosis Models After Angioplasty.- Wire-mediated endovascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia.- Cuff-induced neointima formation in mouse models.- Ligation of the Mouse Common Carotid Artery.- Photochemically Induced Endothelial Injury.- Part IIThrombosis and Hemostasis Models.- Murine Models of Thrombosis and Hemostasis.- Part IIITransplant-Associated Atherosclerosis.- Murine Heart Transplantation and Graft Arterial Disease.- Murine Models of Vein Grafting.- Part IVHyperlipidemia-Induced Atherosclerosis.- Mouse Models of Atherosclerosis.- Part VAneurysm in the Aorta.- Angiotensin II-induced Aortic Aneurysms in Mice.- Mouse model of abdominal aortic aneurysm induced by CaCl2.- Mouse models of aortic aneurysm (tentative).- Part VIIntracranial Aneurysm Models.- Technical aspects of mouse intracranial aneurysm model.- Experimental model of cerebral aneurysms in ovariectomized rats.- PartVIIVascular Disease in Cerebral Arteries.- A model of stroke and vascular injury in the brain.- Part VIIIKawasaki Disease.- Analysis of Kawasaki disease using a mouse model, CAWS vasculitis in DBA/2 mice, induced with a water-soluble extracellular polysaccharide fraction obtained from Candida albicans. <p