Receptor Endocytosis and Signalling in Health and Disease - Part A: Volume 194

Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more.

Other sections in this new release include Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications.

Autorentext
Dr. Indra Mani is an Assistant Professor in the Department of Microbiology, Gargi College, University of Delhi (DU), New Delhi, India. He received M.Sc. in Microbiology from Bundelkhand University (BU), Jhansi, UP, India and Ph.D. in Biochemistry from Banaras Hindu University (BHU), Varanasi, UP, India. He completed postdoctoral training in the Department of Physiology, School of Medicine, Tulane University, New Orleans, USA. He has also worked as a Senior Research Officer (SRO) in the Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India. He has more than 10 years of research and teaching experience in Microbiology, Molecular Genetics, Cell Signaling, and Bioinformatics. He has published 49 articles in peer reviewed journals and 22 book chapters. He has presented several papers in the different national and international conferences. He has extensive experience in fluorescence/confocal microscopy, receptor internalization, trafficking and signaling, molecular cytogenetics, microbial characterization, and in silico analysis. He serves as a reviewer of peer-reviewed journals and also a member of national and international societies. Prof. Vijai Singh is currently serving as Head of the Department of Biosciences, School of Science and Dean (Research & Innovation) at Indrashil University, Rajpur, Mehsana, India. Prior to this, he held the position of Associate Professor in the same department at Indrashil University. He has also served as Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, and in the Department of Biotechnology at the Invertis University, Bareilly, India. Earlier of his career, Prof. Singh worked as a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and at the School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He earned his Ph.D. in Biotechnology in 2009 from the ICAR-National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India. His doctoral research focused on the development of molecular and immunoassays for the diagnosis of Aeromonas hydrophila. Prof. Singh's research interests lies in the design and construction of novel biosynthetic pathways for production of medically and industrially important biomolecules. His laboratory is also actively engaged in developing CRISPR-Cas systems for gene knock out, knock in, gene regulation and diagnostic. With over 15 years of research and teaching experience, his areas of expertise include synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has an extensive academic record, with over 110 articles, 89 book chapters, 26 books and 3 patents to his credits. Prof. Singh has received number of prestigious awards, including the Bioclues Innovation, Research and Development Award (2023) from the BIOCLUES Society, the Vice Chancellor's Best Research Award (2023) from Indrashil University, and the Agathiyar Chemical Biology Award (2023) from the Society of Chemical and Synthetic Biology. At Indrashil University, he currently serves as chairman of the Board of Study, and is a member of the Academic Council of Indrashil University. He also holds the position of the Member Secretary of the Institutional Biosafety Committee (IBSC) at the university. Dr. Singh is actively involved in national and international scientific advisory roles.

Inhalt

Preface * Indra Mani and Vijai Singh

• 1. An overview of receptor endocytosis and signaling
  * Indra Mani and Vijai Singh
• 2. Emerging tools for studying receptor endocytosis and signaling
  * Pratiksha Pandita, Rhea Bhalla, Ashok Saini and Indra Mani
• 3. Mas receptor endocytosis and signaling in health and disease
  * Natalia L. Rukavina Mikusic and Mariela M. Gironacci
• 4. Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants
  * Shivranjani C Moharir, Kapil Sirohi and Ghanshyam Swarup
• 5. The insulin receptor endocytosis
  * Jiayi Wu, Stella Hayoung Park and Eunhee Choi
• 6. VEGFR endocytosis: Implications for angiogenesis
  * Queen Saikia, Hannah Reeve, Areej Alzahrani, William R. Critchley, Elton Zeqiraj, Aysha Divan, Michael A. Harrison and Sreenivasan Ponnambalam
• 7. Endocytosis and signaling of angiotensin II type 1 receptor
  * Indra Mani
• 8. B cell receptor (BCR) endocytosis
  * Aleah D. Roberts and Justin W. Taraska
• 9. Multifunctional role of the ubiquitin proteasome pathway in phagocytosis
  * Angela Lalnunthangi, Gyaltsen Dakpa and Swati Tiwari
• 10. Receptors of immune cells mediates recognition for tumors * Vandana Anang, Aayushi Singh, Sarat Kumar Kottarath and Chaitenya Verma
• 11. Role of lymphocytes, macrophages and their receptors in mediating suppression of tumor immunity * Aayushi Singh, Vandana Anang, Komal Kumari, Sarat Kumar Kottarath and Chaitenya Verma
• 12. Adrenoceptors and SCD1 in adipocytes/adipose tissues: The expression and variation in health and obesity * Dinh-Toi Chu, Nhat-Le Bui and Ngoc Hoan Le
• 13. Low density lipoprotein receptor endocytosis in cardiovascular disease and factors affecting LDL levels * Rupesh Maurya, Gargi Bhattacherjee, Nisarg Gohil, Khushal Khambhati, Shreya Shakhreliya, Aaradhya Bhatnagar, Priyanka Singh, Suresh Ramakrishna and Vijai Singh
• 14. Endocytosis of LXRs: Signaling in liver * Mettle Brahma, Soumika Ghosal, Mulaka Maruthi and Suresh K. Kalangi
• 15. Frizzled receptors and SFRP5 in lipid metabolism: Current findings and potential applications Dinh-Toi Chu and Thanh-Lam Nguyen