Role of Signaling Pathways in Brain Tumorigenesis

This book illustrates the details of origin of brain tumors and mechanism of progression.2. - It represents a comprehensive overview of the role of various cell signaling pathways in brain tumour development. 3. - It illustrates the mechanism of pathway activation to tumor growth and therapeutic approach for brain tumor treatment

Autorentext

Dr. Mehdi Hayat Shahi is an Assistant Professor at the Interdisciplinary Brain Research Centre, Aligarh Muslim University, Aligarh. Before joining AMU, he was a postdoctoral fellow at University of California, Davis, USA from 2010-2014. He was also an instructor at the University California Davis besides his postdoctoral research. From 2009-2010, he worked as a postdoctoral research fellow at Uppsala University, Uppsala, Sweden. His current research interests are focused on molecular neuro-oncology. Towards this pursuit, he is exploring the early stem cell biomarkers that can be utilized for the early diagnosis of brain tumours and other neurodegenerative diseases. He has been honored with many prestigious awards notably, Farah Deeba Award from the Indian Academy of Biomedical Sciences for an outstanding researcher in biomedical sciences, Outstanding Scientist Award for Neuro-oncology research from the Venus International Foundation. He has also served as a referee for thenumber of international journals, including, PLoS One and Tumour Biology. He has 12 years of research experience in molecular brain tumour biology and 4 years of teaching experience.He has published more than 21 research articles in the peer-reviewed international journals and co-authored two book chapters. He has served as a Co-chair of the Post-doctoral Scholar Association, University of California, USA, from 2013-2014. He is a member of many International Scientific Societies and Organizations importantly International Society for Neurochemistry, Indian Academy of Neurosciences, Indian Association for Cancer Research, and Indian Academy of Biomedical Sciences.

Inhalt
Introduction of Cell signalling Pathways and Brain Tumours.- Wnt cell signalling pathway and brain tumours development.- Notch cell signalling pathway and Brain Tumours.- Shh cell signalling pathway and paediatric brain tumour Medulloblastoma.- Role of Shh cell signalling pathway in glioma.- Role of stem cell marker NANOG in brain tumours development.- Stem cell factor Sox2 and Brain Tumours Development.- Role of Neurotrophins in brain tumor development.- Role of NFk in brain tumour development.- Role of Myc in brain tumours development.- Role of P53 in Medulloblastoma Development.- Role of Gene TP53 in glioblastoma development.- Role of HIF-1 in Brain Tumour Development.- EGFR and its role in glioma development.- Role of EFGR in medulloblastoma development.- Role of OCT4 in glioblastoma development.- Role of OCT4 in paediatric brain tumour medulloblastoma development.- Role of Mitogen activated protein (MAP) Kinase in paediatric brain tumour medulloblastoma