Secretory Proteins: Volume 133

Tout ce qu'il faut savoir sur L'Homme qui Rit de Victor Hugo en seulement dix pages ! Retrouvez l'essentiel de l'oeuvre dans un dossier complet et détaillé, avec un résumé, une étude des personnages, des clés de lecture et des pistes de réflexion pour préparer le bac. Rédigé de manière claire et accessible, le dossier propose d'abord un résumé partie par partie du roman, puis s'intéresse aux personnages, en particulier à Ursus, misanthrope solitaire, et à Gwynplaine, l'Homme qui Rit . On aborde ensuite la notion d'excès présente dans le roman, le thème de la fatalité au travers des motifs de la mer et de la tempête, ainsi que les connotations politiques et révolutionnaires de cette oeuvre romantique. Un dossier de référence, idéal pour réviser ou préparer un cours.

Autorentext
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

Inhalt

1. Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway
   Laura Cendron, Sylvia Rothenberger, Leonardo Cassari, Monica Dettin, and Antonella Pasquato
2. Exploring the macromolecules for secretory pathway in cancer disease
   Chandrabose Selvaraj, Umesh Panwar, Karthik Raja Ramalingam, Rajendran Vijayakumar, and Sanjeev Kumar Singh
3. Current and emerging biomarkers in ovarian cancer diagnosis: CA125 and beyond
   Tarang Sharma, Sabah Nisar, Tariq Masoodi, Muzafar A. Macha, Shahab Uddin, Ammira Al-Shabeeb Akil, Tej K. Pandita, Mayank Singh, and Ajaz A. Bhat
4. Senescent cells and SASP in cancer microenvironment: New approaches in cancer therapy
   Aysun Ozdemir, Yaprak Dilber Simay Demir, Zeynep Elif Yesilyurt, and Mustafa Ark
5. Autophagy for secretory protein: Therapeutic targets in cancer
   Kewal Kumar Mahapatra, Srimanta Patra, Soumya Ranjan Mishra, Bishnu Prasad Behera, Shankargouda Patil, and Sujit Kumar Bhutia
6. The role of SPARC/ON in human osteosarcoma
   Consolato M. Sergi
7. The secretory phenotypes of envenomed cells: Insights into venom cytotoxicity
   Y. Yong, J.J. Hiu, and M.K.K. Yap
8. Exploring the role of secretory proteins in the human infectious diseases diagnosis and therapeutics
   Elora Kalita, Mamta Panda, Abhishek Rao, and Vijay Kumar Prajapati
9. Secretory proteins in the orchestration of microbial virulence: The curious case of Staphylococcus aureus
   Dileep Francis, Anusha Bhairaddy, Atheene Joy, Gopika Veeramanickathadathil Hari, and Ashik Francis
10. Structure-based virtual screening to identify potential lipase inhibitors to reduce lipid storage in Wolman disorder
    Karthick Vasudevan, S. Udhaya Kumar, A. Mithun, B. Raghavendra, and C. George Priya Doss