Semiconducting Silicon Nanowires for Biomedical Applications

Informationen zum Autor Jeffrey Coffer is Professor of Inorganic and Materials Chemistry at Texas Christian University, Fort Worth. His research interests are in the preparation and properties of semiconductor nanocrystals and nanowires, luminescent silicon-based materials, rare-earth-doped semiconductor nanostructures, and nanophase biomaterials. Klappentext The unique fundamental physico-chemical properties of semiconductor silicon nanowires provide a diverse toolbox from which scientists are tackling significant problems in human health at the nanoscale. Biological systems at both the in vitro and in vivo levels are being investigated as is the fabrication, surface chemistry, and electronic properties of such materials. This book seeks to address the most critical range of issues emerging in this important field and its applications. Part one provides readers with a comprehensive overview of the field and fundamental technologies. Chapters in part two look at tissue engineering and selected drug delivery therapies. The final set of chapters address biomolecular detection and sensing applications of silicon nanowires. Inhaltsverzeichnis Contributor contact details Woodhead Publishing Series in Biomaterials Foreword Part I: Introduction to silicon nanowires for biomedical applications 1. Overview of semiconducting silicon nanowires for biomedical applications Abstract: 1.1 Introduction 1.2 Origins of silicon nanowires 1.3 The structure of this book 1.4 Conclusion 1.5 References 2. Growth and characterization of semiconducting silicon nanowires for biomedical applications Abstract: 2.1 Introduction 2.2 Synthesis methods for silicon nanowires (SiNWs) 2.3 Characterization methods 2.4 Synthesis of semiconductor SiNWs by the chemical vapor deposition (CVD) method 2.5 Conclusion 2.6 Future trends 2.7 Sources of further information and advice 2.8 References 3. Surface modification of semiconducting silicon nanowires for biosensing applications Abstract: 3.1 Introduction 3.2 Methods for fabricating silicon nanowires (SiNWs) 3.3 Chemical activation/passivation of SiNWs 3.4 Modification of native oxide layer 3.5 Modification of hydrogen-terminated silicon nanowires (H-SiNW) 3.6 Site-specific immobilization strategy of biomolecules on SiNWs 3.7 Control of non-specific interactions 3.8 Conclusion References 4. Biocompatibility of semiconducting silicon nanowires Abstract: 4.1 Introduction 4.2 In vitro biocompatibility of silicon nanowires (SiNWs) 4.3 In vivo biocompatibility of SiNWs 4.4 Methodology issues 4.5 Future trends 4.6 Conclusion 4.7 References Part II: Silicon nanowires for tissue engineering and delivery applications 5. Functional semiconducting silicon nanowires for cellular binding and internalization Abstract: 5.1 Motivation: developing a nano-bio model system for rational design in nanomedicine 5.2 Methods: non-linear optical characterization and surface functionalization of silicon nanowires (SiNWs) 5.3 Applications: in vivo imaging and in vitro cellular interaction of functional SiNWs 5.4 Conclusions and future trends 5.5 References 6. Functional semiconducting silicon nanowires and their composites as orthopedic tissue scaffolds Abstract: 6.1 Introduction 6.2 Nanowire surface etching processes to induce biomineralization 6.3 Nanowire surface functionalization strategies to induce biomineralization 6.4 Construction of silicon nanowire (SiNW)-polymer scaffolds: mimicking trabecular bone 6.5 The role of SiNW orientation in cellular attachment, proliferation and differentiation in the ...

Klappentext

The unique fundamental physico-chemical properties of semiconductor silicon nanowires provide a diverse toolbox from which scientists are tackling significant problems in human health at the nanoscale. Biological systems at both the in vitro and in vivo levels are being investigated as is the fabrication, surface chemistry, and electronic properties of such materials. This book seeks to address the most critical range of issues emerging in this important field and its applications. Part one provides readers with a comprehensive overview of the field and fundamental technologies. Chapters in part two look at tissue engineering and selected drug delivery therapies. The final set of chapters address biomolecular detection and sensing applications of silicon nanowires.

Inhalt

Contributor contact details

Woodhead Publishing Series in Biomaterials

Foreword

Part I: Introduction to silicon nanowires for biomedical applications

1. Overview of semiconducting silicon nanowires for biomedical applications

   Abstract:

   1.1 Introduction

   1.2 Origins of silicon nanowires

   1.3 The structure of this book

   1.4 Conclusion

   1.5 References

2. Growth and characterization of semiconducting silicon nanowires for biomedical applications

   Abstract:

   2.1 Introduction

   2.2 Synthesis methods for silicon nanowires (SiNWs)

   2.3 Characterization methods

   2.4 Synthesis of semiconductor SiNWs by the chemical vapor deposition (CVD) method

   2.5 Conclusion

   2.6 Future trends

   2.7 Sources of further information and advice

   2.8 References

3. Surface modification of semiconducting silicon nanowires for biosensing applications

   Abstract:

   3.1 Introduction

   3.2 Methods for fabricating silicon nanowires (SiNWs)

   3.3 Chemical activation/passivation of SiNWs

   3.4 Modification of native oxide layer

   3.5 Modification of hydrogen-terminated silicon nanowires (H-SiNW)

   3.6 Site-specific immobilization strategy of biomolecules on SiNWs

   3.7 Control of non-specific interactions

   3.8 Conclusion

   References

4. Biocompatibility of semiconducting silicon nanowires

   Abstract:

   4.1 Introduction

   4.2 In vitro biocompatibility of silicon nanowires (SiNWs)

   4.3 In vivo biocompatibility of SiNWs

   4.4 Methodology issues

   4.5 Future trends

   4.6 Conclusion

   4.7 References

   Part II: Silicon nanowires for tissue engineering and delivery applications

5. Functional semiconducting silicon nanowires for cellular binding and internalization

   Abstract:

   5.1 Motivation: developing a nano-bio model system for rational design in nanomedicine

   5.2 Methods: non-linear optical characterization and surface functionalization of silicon nanowires (SiNWs)

   5.3 Applications: in vivo imaging and in vitro cellular interaction of functional SiNWs

   5.4 Conclusions and future trends

   5.5 References

6. Functional semiconducting silicon nanowires and their composites as orthopedic tissue scaffolds

   Abstract:

   6.1 Introduction

   6.2 Nanowire surface etching processes to induce biomineralization

   6.3 Nanowire surface functionalization strategies to induce biomineralization

   6.4 Construction of silicon nanowire (SiNW)-polymer scaffolds: mimicking trabecular bone

   6.5 The role of SiNW orientation in cellular attachment, proliferation and differentiation in the nanocomposite

   6.6 Conclusions and future trends

   6.7 Acknowledgement

   6.8 References

7. Mediated differentiation of stem cells by engineered semiconducting silicon nanowires

   Abstract:

   7.1 Introduction

   7.2 Methods for fabricating silicon nanowires (SiNWs)

   7.3 Regulated differentiation for human mesenchymal stem cells (hMSCs)

   7.4 SiNWs fabricated by the electroless metal deposition (EMD) method and their controllable spring constants

   7.5 Mediated differentiation of stem cells by engineered SiNWs

   7.6 Conclusion

   7.7 Future trends

   7.8 Acknowledgements

   7.9 References

8. Silicon nanoneedles for drug delivery

   Abstract:

   8.1 Introduction

   8.2 Strategies for nanoneedle fabrication

   8.3 Drug loading of nanoneedles and release patterns

   8.4 Drug delivery using nanoneedles

   8.5 Toxicity of nanoneedles

   8.6 Overview of nanoneedle applications

   8.7 Conclusion

   8.8 References

   Part III: Silicon nanowires for detection and sensing

9. Semiconducting silicon nanowire array fabrication for high throughput screening in the biosciences

   Abstract:

   9.1 Introduction

   9.2…