Solid Lipid Nanoparticles: In-vitro/In-vivo Characterization

Delivery of drugs to the brain is a major challenge due to the presence of the blood brain barrier. To reach therapeutic drug level in the brain, nanoparticulate systems are being recently investigated as potential drug carriers due to their high loading capacity, small particle size and ability to bypass the Reticulo Endothelial System. Nanoparticles in fact, are solid colloidal particles ranging in size from 1 to 1000 nm and are composed of macromolecular material which could be polymeric or lipidic. Solid lipid nanoparticles (SLNs) are taken up readily by the brain because of their lipidic nature. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. SLN have been found to improve the permeability of drug through the blood brain-barrier and is a promising drug targeting system for the treatment of central nervous system disorders.

Autorentext

Manish Jindal Senior Research Fellow Dept. Pharm Sci & Drug Res. Punjabi University Patiala manishjindal1984@gmail.com