Synthesis, Antioxidant and Antimicrobial Activity of New Thiophene

In the current scenario, the Gewald synthesis mechanism was used to synthesize a series of 11 newly designed thiophene analogs (D1-D11) derivatives using (Scheme-1, D1-D11). FTIR, 1H-NMR are used for the characterization of the newly synthesized analogs. After structural characterization, these derivatives are then screened for their in vitro biological evaluation. The biological evaluation of designed thiophene analogs was performed to test their antibacterial, antifungal and antioxidant action. Among all the designed and synthesized analogs, compounds D11 and D6 exhibit strong antibacterial action against Escherichia coli and Bacillus subtilis. Compound D3 and D11 has the strongest antifungal properties towards Aspergillus clavatus Compound D3 and D11 produces the greatest antioxidant activity with an IC50 value of 51.18 and 49.60.

Autorentext
Ms. Manisha devi. and Mr. Kaushal Arora is working as research scholar under the supervision of Prof. Prabhakar Kumar Verma , Department of Pharmaceutical sciences M.D .University, Rohtak, Haryana.Prof. Prabhakar Kumar Verma is working as Professor of Pharma Chemistry with Department of Pharmaceutical sciences M.D. University, Rohtak, Haryana.