The Epigenome and Developmental Origins of Health and Disease

Winner of 2016 BMA Medical Award for Basic and Clinical Sciences

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring.

The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring.

It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples.

Autorentext
Cheryl S. Rosenfeld, DVM, PhD, has published extensively on how maternal diet and developmental exposure to endocrine-disrupting compounds affect offspring outcomes. She has written several review articles and book chapters, including the most recent one on animal models of transgenerational epigenetic effects in Transgenerational Epigenetics: Evidence and Debate, published by Elsevier. She also edited and coauthored the book The Epigenome and Developmental Origins of Health and Disease, which won the BMA Medical Award for Basic and Clinical Sciences in 2016.

Klappentext

Winner of 2016 BMA Medical Award for Basic and Clinical Sciences

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring.

The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring.

It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples.

Inhalt

1. The Developmental Origins of Health and Disease (DOHaD) concept: past, present and future.
   
   2. Historical Perspective of Developmental Origins of Health and Disease in Humans
   3. DOHaD and the Periconceptional Period, a Critical Window in Time
   4. Introduction to Epigenetic Mechanisms: The Probable Common Thread for Various Developmental Origins of Health and Diseases Effects
   5. Fetal Neuro-Hormonal Programming and Endocrine Disruption
   6. Parental nutrition and developmental origins of health and disease
   7. Maternal prenatal stress and the developmental origins of mental health: the role of epigenetics
   8. Epigenetics in the Developmental Origin of Cardiovascular Disorders
   9. Developmental Effects of Endocrine-Disrupting Chemicals in the Ovary and on Female Fertility
   10. Developmental and Epigenetic Origins of Male Reproductive Pathologies
   11. Developmental Origins of Childhood Asthma and Allergic Conditions - is there evidence of epigenetic regulation?
   12. Immune Disorders, Epigenetics, and the Developmental Origins of Health and Disease
   13. Neurobehavioral Disorders and DOHaD
   14. Metabolic Disorders and DOHaD
   15. The developmental origins of renal dysfunction
   16. Cancer and DOHaD- Epigenetic reprogramming as a mediator
   17. Epigenetic regulation of gastrointestinal epithelial barrier and developmental origin of health and disease
   18. How the Father might Epigenetically Program the Risk for Developmental Origins of Health and Disease Effects in his Offspring
   19. Linkage Between in Utero Environmental Changes and Preterm Birth
   20. Sexual Dimorphism and DOHaD Through the Lens of Epigenetics
   21. Transgenerational Epigenetic Inheritance: Past Exposures, Future Diseases
   22. The Placenta and DOHaD
   23. The Moral and Legal Relevance of DOHaD Effects for Pregnant Mothers
   24. Introduction to Moms in Motion (MIM) Chapter
   25. Reversing Harmful DOHaD Effects
   26. Informational Resources for Developmental Origins of Health and Disease Research