The Mitochondrion in Aging and Disease: Volume 127

Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed.

Autorentext

Professor Heinz D. Osiewacz leads the group on Molecular Developmental Biology at the Goethe University in Frankfurt/ Main, Germany. He has a long-standing experience in the field of experimental gerontology. For his work on molecular mechanisms of ageing he received in 1985, together with Profs. K. Esser, U. Kück, U. Stahl and P. Tudzynski the Sandoz Prize of Gerontology by the International Association of Gerontology and in 2001 the Rene-Schubert Prize for Gerontology by the German Society of Gerontology. From 1990-1994 he was head of the department Molecular Biology of Ageing Processes at the German Cancer Research Center (DKFZ), Heidelberg, Germany. Since 1994 he is Professor at the University of Frankfurt. He edited (co-edited) five books, is co-author of one book, and published over 140 peer-reviewed research and review articles, respectively. H.D. Osiewacz is in the editorial board of Biogerontology, Current Genetics, Eukaryotic Cell Experimental Gerontology, Mechanisms of Ageing and Development, Microbial Cell. He was the coordinator of an integrated project of the European Commission on the role of mitochondria in conserved mechanisms of ageing (Acronym: MiMage). He participated in various EC projects and coordinated a national project of the German Federal Ministry for Education and Research (BMBF) on systems biology, mitochondria and aging (GerontoMitoSys).

The scientific work of his research group in the field of ageing research is devoted to unravel the molecular network of pathways controlling ageing in the fungal ageing model Podospora anserina. In particular, mitochondrial/nuclear interactions (cross talk), mitochondrial DNA instabilities and mtDNA repair, respiration, retrograde signalling, ROS generation and scavenging, apoptosis, mitochondrial dynamics, protein quality control, and autophagy are investigated at the genetic, biochemical, cytological, and physiological level. A central issue of the research is the analysis of long-lived mutants and of specific transgenic strains to raise functional and mechanistic data.

Klappentext

Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed.

Inhalt

1. The Mitochondrial Free Radical Theory of Aging
   *Gustavo Barja*
2. Mitochondrial DNA Mutations in Aging
   *Konstantin Khrapko and Doug Turnbull*
3. Mathematical Models of Mitochondrial Aging and Dynamics
   *Axel Kowald and Edda Klipp*
4. Mitochondrial Dynamics in Aging and Disease
   *Jürgen Bereiter-Hahn*
5. The Retrograde Response - A Conserved Compensatory Reaction to Damage from Within and from Without
   *S. Michal Jazwinski*
6. Mitochondrial Acetylation and Genetic Models of Parkinson's Disease
   *Georg Auburger, Suzana Gispert and Marina Jendrach*
7. Mitochondrial Dysfunction: Cause and Consequence of Alzheimer's Disease
   *Kristina Friedland-Leuner, Carola Stockburger, Isabel Denzer, Gunter P. Eckert and Walter E. Müller*
8. Mitochondria in Cancer: Why Mitochondria are a Good Target for Cancer Therapy
   *Lan-Feng Dong and Jiri Neuzil*
9. Estrogen and Mitochondria Function in Cardiorenal Metabolic Syndrome
   *Guanghong Jia, Annayya R. Aroor and James R. Sowers*
10. Advances in Development of Rechargeable Mitochondrial Antioxidants
    *Alexander N. Lukashev, Maxim V. Skulachev, Victoria Ostapenko, Alla Yu. Savchenko, V. V. Pavshintsev and Vladimir P. Skulachev
    *