The Vertebrate Blood-Gas Barrier in Health and Disease

This comprehensive volume on the blood-gas barrier (BGB) among vertebrates covers its structure and composition along with aspects of evolution, bioengineering, and morphometry. The book also discusses the embryological development of the BGB, including chronology of events and molecular control in vertebrates; modulation of the barrier function, including cyclic stretch-induced increases in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; transport mechanisms of the BGB, including sodium transport channels; factors affecting trans-barrier traffic of fluids, such as chronic elevation of pulmonary microvascular pressure; stress failure; regulation and repair in acute lung injury; chronic lung disease; and lung transportation.

Ten authoritative chapters approach the blood-gas barrier holistically, from basic structure and development to pathology and treatment. Properties of the BGB are discussed in the earlier chapters, followed by prenatal and post-natal development and mechanisms of the healthy BGB. The latter half of the book delves into the pathology of the BGB, analyzing common afflictions and exploring options for treatment, including its alterations during lung transplantation. Intuitively structured and comprehensive, The Vertebrate Blood-Gas Barrier in Health and Disease is ideal for researchers and clinicians interested in pneumology and angiology.

The first book to give the blood-gas barrier a holistic approach; from basic structure to development, pathology and treatment Covers the broad scope of the vertebrata, while laying emphasis on humans Emphasizes the current trends, especially the molecular biology of the topics Includes supplementary material: sn.pub/extras

Autorentext

About the Editor

Dr. Andrew N Makanya received his MSc and PhD from the University of Nairobi in Nairobi, Kenya, and his Doctor of Veterinary Medicine from the University of Bern in Bern, Switzerland. He is Senior Lecturer in the Department of Veterinary Anatomy and Physiology at the University of Nairobi and is a practicing veterinary surgeon. His research interests include lung development and function, angiogenesis, and differentiation and remodeling of the blood-gas barrier, and he has published widely in these areas. Dr. Makanya is also chairman of the Board of Governors of two secondary schools in Kenya, and participates actively in community development programs focusing on schools, churches, and children's homes.

Inhalt

Chapter 1 Generalities of gas diffusion applied to the vertebrate blood-gas barriers.- Chapter 2 Morphological and morphometric properties of the blood-gas barrier: comparative perspectives.- Chapter 3 Prenatal and postnatal development of the vertebrate blood-gas barrier.- Chapter 4 Molecular mechanisms regulating the pulmonary blood-gas barrier (BGB).- Chapter 5 Barrier enhancing signals.- Chapter 6 Trans-barrier ion and fluid transport.- Chapter 7 Stress failure of the pulmonary blood-gas barrier.- Chapter 8 The lung endothelial barrier in acute inflammation.- Chapter 9 Lung transplantation and the blood-gas-barrier.- Chapter 10 Stereological studies on transient gas-exchangers, with emphasis on the structure and function of the human placenta in normal and compromised pregnancies.