Translational Methods for Multiple Sclerosis Research

This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt
Pathophysiological Bases of Autoimmune Initiated/Mediated Neurodegeneration.- Translational Animal Models for MS and Related Neuroimmunological Disorders.- White Matter Pathology.- Pathophysiology of Grey Matter Affection in MS.- Translational Characterization of Glia Role in Multiple Sclerosis.- Translational Value of CSF and Blood Markers of Autoimmunity and Neurodegeneration.- Spontaneous Mouse Models of Neuroinflammation.- Chronic Progressive Models.- Electrophysiological Measurements of Brain Network Characterization in Rodents.- Translation of Functional Domain Abnormalities from Human to Mouse Motor System.- Characterization of the Somatosensory System.- Translational Research in Neuroimmunology: Cognition.- Models for Assessing Anxiety and Depression in Multiple Sclerosis: From Mouse to Man.- Human Structural MRI.- Human Functional MRI.- Functional Studies in Rodents.- Non-Invasive Electrophysiology.- Targeting Acute Inflammation.- Translational Aspects of Immunotherapeutic Targets in MS.- Therapeutic Strategies to Potentially Cure Multiple Sclerosis: Insights into the Mechanisms of Autologous Hematopoietic Stem Cell Transplantation.- Symptomatic MS Therapy.