2-Pyrazoline-1-Carboxamide Derivatives

2-Pyrazoline derivatives are synthesized by diverse reaction schemes and display a broad spectrum of potential pharmacological activities. The derivatives are present in numerous pharmacologically active molecules such as azolid/ tandearil (anti-inflammatory), phenazone/ amidopyrene/ methampyrone (analgesic and antipyretic), anturane (uricosuric) and indoxacarb (insecticide). New therapeutic agents having improved potency and lesser toxicity are developed by changing in their structure, and it has offered a high degree of diversity that has proven useful for the new drug development. The aim of the present research was thus focused on 2-pyrazoline-1-carboxamide derivatives. The 2-pyrazoline-1-carboxamide derivatives were synthesized by convenient, economical methods in less reaction time and with better yield of products with high level of purity. The compounds numbered 4d-4e, 4j-4k, and 4m-4t were most protective against MES even at 30 mg/kg dose levels. The synthesized compounds were showing minimal neurotoxicity. Thus, it is concluded that all the tested compounds are protective against MES at 100-300 mg/kg dose levels and show promising anticonvulsant activity.

Autorentext

Dr. Md Azizur Rahman is working as an Associate Professor of Pharmaceutical Chemistry, Department of Pharmacy, Faculty of Pharmacy, Integral University, and Dr. Anees A. Siddiqui was Ex-Professor of Pharmaceutical Chemistry, Department of Pharmaceutical Chemistry, Faculty of Pharmacy (SPER), Jamia Hamdard (Hamdard University), New Delhi, India.