A2A Receptor Mediated Relaxation via NOS Pathway in Diabetic Rat Aorta

Diabetes is characterized by hyperglycemia. It is a metabolic disease caused due to insufficient secretion or action of endogenous insulin. Diabetes is always associated with cardiovascular diseases. Accumulation of atheromatous plaque with in the walls of the coronary arteries results in atherosclerotic heart disease. Adenosine receptors plays an important role in regulation of coronary heart flow by controlling the blood vessels contraction and relaxation . Here we have studied the A2A receptor mediated relaxation in diabetic rat aorta and its signalling pathway. The results obtained showed that there is reduction in the relaxation of diabetic rat aorta as compared with the normal rat aorta both in the presence and absence of endothelium. It was also noted that there is significantly higher ROS generation in diabetic rat aorta in comparison to normal healthy rats. So we can conclude that diabetes may induce change in the expression level of adenosine receptor and finally lower aorta relaxation. these changes correspond to some cardiovascular complications observed in diabetes.

Autorentext

Jogendra S Pawar Born in India, is a PhD student in Biochemistry Lab. SES, Jawaharlal Nehru University, New Delhi, India. He obtained his MSc. Biosciences from Jamia Millia Islamia University, New Delhi. His BSc. Life Sciences is from Sri Venkateswara College, University of Delhi, India. His research interest includes Cell signalling and proteomics